Evidence map›Paper›PMID 37043535›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction.

Derek C K Chan, Inokentijs Josts, Kalinka Koteva, Gerard D Wright, Henning Tidow, Lori L Burrows

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Siderophore-Porphyrin conjugates for bacteria-selective antimicrobial photodynamic therapy.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  3. Article
  4. Review
  5. Flavin-containing siderophore-interacting protein of Shewanella putrefaciens DSM 9451 reveals common structural and functional aspects of ferric-siderophore reduction.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Nutrient Limitation SensitizesACS infectious diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Derek C K ChanDavid Braley Center for Antibiotic Discovery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-0388-5417
Inokentijs JostsThe Hamburg Advanced Research Center for Bioorganic Chemistry, Hamburg 22761, Germany.ORCID 0000-0002-8235-2397
Kalinka KotevaDavid Braley Center for Antibiotic Discovery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0002-6446-9567
Gerard D WrightDavid Braley Center for Antibiotic Discovery, McMaster University, Hamilton, ON L8S 4K1, Canada.
Henning TidowThe Hamburg Advanced Research Center for Bioorganic Chemistry, Hamburg 22761, Germany.ORCID 0000-0002-4702-9332
Lori L BurrowsDavid Braley Center for Antibiotic Discovery, McMaster University, Hamilton, ON L8S 4K1, Canada.ORCID 0000-0003-0838-5040
McMaster University · CAUniversität Hamburg · DE

Funding

Canada Research Chairs (Chaires de recherche du Canada) Tier 1Deutsche Forschungsgemeinschaft (DFG) DFG EXC 1074Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) CGS-DGouvernement du Canada | Canadian Institutes of Health Research (IRSC) FRN-148463Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2021-04237
6 · The paper itself

Abstract

The outer membrane of gram-negative bacteria prevents many antibiotics from reaching intracellular targets. However, some antimicrobials can take advantage of iron import transporters to cross this barrier. We showed previously that the thiopeptide antibiotic thiocillin exploits the nocardamine xenosiderophore transporter, FoxA, of the opportunistic pathogen

Indexed as

Anti-Bacterial AgentsSiderophoresBacterial Outer Membrane ProteinsBacterial ProteinsIronLigandsMembrane Transport ProteinsPseudomonas aeruginosaSignal TransductionAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsIronLigandsMembrane Transport ProteinsSiderophoresantibiotic uptakeiron acquisitionPseudomonas aeruginosasiderophoresthiocillin

Identifiers

PMID37043535
PMCPMC10120069
OpenAlexW4365136280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.