Evidence map›Paper›PMID 37043353›Full record

ArticleCell reports2023

Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain.

Ricardo L Azevedo-Pereira, Nathan C Manley, Chen Dong, Yue Zhang, Alex G Lee, Yulia Zatulovskaia, Varun Gupta, Jennifer Vu, Summer Han, Jack E Berry and 2 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ricardo L Azevedo-PereiraDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Nathan C ManleyDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Chen DongDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Yue ZhangStanford Genetics Bioinformatics Service Center, Stanford University, Stanford, CA 94305, USA.
Alex G LeeDivision of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, CA 94143, USA.
Yulia ZatulovskaiaDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Varun GuptaDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Jennifer VuDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Summer HanDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Jack E BerryDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Tonya M BlissDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: tbliss1@stanford.edu.
Gary K SteinbergDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: gsteinberg@stanford.edu.
Stanford University · USStanford Medicine · USUniversity of California, San Francisco · US

Funding

Paracrine and synaptic mechanisms underlying recovery using human stem cell theraR01NS058784 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2008 to 2023
$6.6M
NINDS NIH HHS R01 NS058784
6 · The paper itself

Abstract

Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action.

Indexed as

Neural Stem CellsStrokeAnimalsBrainCell DifferentiationHumansRatsStem Cell TransplantationBMP6CP: NeuroscienceCP: Stem cell researchmechanismNOGRNA-seqstem cellstroketranscriptometransplantTRAP

Identifiers

PMID37043353
PMCPMC10562513
OpenAlexW4363672327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.