Evidence map›Paper›PMID 37043306›Full record

ArticleMolecular biology of the cell2023

The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during

Austin Baldwin, Ivan K Popov, Ray Keller, John Wallingford, Chenbei Chang

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Austin BaldwinDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0002-6099-0873
Ivan K PopovDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Ray KellerBiology Department, University of Virginia, Charlottesville, VA 22903.
John WallingfordDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.
Chenbei ChangDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.

Funding

Molecular and cell biological basis of convergent extensionR01HD099191 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI John B Wallingford · 2020 to 2026
$2.7M
Regulation of apical constriction of bottle cells by the RhoGEF protein Plekhg5 during gastrulation morphogenesisR01GM127371 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHANG, CHENBEI · 2019 to 2022
$1.5M
Dynamic analysis of apical constriction activity during neural tube closureF32HD094521 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI BALDWIN, AUSTIN · 2018 to 2020
$162k
NICHD NIH HHS F32 HD094521NICHD NIH HHS R01 HD099191NIGMS NIH HHS R01 GM127371
6 · The paper itself

Abstract

Apical constriction results in apical surface reduction in epithelial cells and is a widely used mechanism for epithelial morphogenesis. Both medioapical and junctional actomyosin remodeling are involved in apical constriction, but the deployment of medial versus junctional actomyosin and their genetic regulation in vertebrate embryonic development have not been fully described. In this study, we investigate actomyosin dynamics and their regulation by the RhoGEF protein Plekhg5 in

Indexed as

ActomyosinGastrulationActinsAnimalsConstrictionMorphogenesisRho Guanine Nucleotide Exchange FactorsXenopus laevisActinsActomyosinRho Guanine Nucleotide Exchange Factors

Identifiers

PMID37043306
PMCPMC10295481

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.