ArticleVeterinary medicine and science2023
Effects of exposure to the inhalational anaesthetic sevoflurane on the male reproductive system in rats.
Article in Veterinary medicine and science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Effect of repeated xylazine-ketamine or medetomidine-ketamine administration on selected reproductive parameters in male rats.Iranian journal of veterinary research · 2025Article
- Morphometric analysis of the female reproductive tract: influence of long-term inhalation of trace amounts of sevoflurane.Journal of molecular histology · 2024Article
- Effects of exposure to the inhalational anaesthetic sevoflurane on the male reproductive system in rats.Veterinary medicine and science · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to explore the effects of inhalational anaesthetics on the male reproductive system in neonatal rats.
methodsPostnatal day 6 (P6) male rat pups were assigned to 2 groups of 40 rats each. The control group did not receive anaesthesia, and the test group was exposed to air containing 3% sevoflurane in a chamber. After sevoflurane exposure, the effects on the male reproductive system in neonatal rats exposed to inhalational anaesthetics were tested. The rats were maintained to P60. The fertility, sperm and spermatid count, sperm motility, organ weights and histological changes in rats were determined.
resultsCompared with those of the control group, the sperm count and motility of the sevoflurane group were significantly decreased (p < 0.05), and there was also a decrease in the number of foetal rats from the sevoflurane group (p < 0.05). Furthermore, the arrangement of the seminiferous tubule was regular in the control group, whereas the arrangement of the seminiferous tubule was distorted and the spermatocytes were detached and irregularly lined in the sevoflurane group. TUNEL analysis showed that the number of apoptotic cells in the testes of the sevoflurane group was significantly increased (p < 0.05). SOD and MDA analyses showed that SOD was decreased, while MDA expression was increased.
conclusionsThese data indicated that young rats suffered as a result of inhalation of the anaesthetic sevoflurane and had reduced reproductive system function during adolescence in males. These studies are useful as a foundation for clinical studies.
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