Evidence map›Paper›PMID 37043156›Full record

ArticleInternational urology and nephrology2023

Parasympathetic activity and total fibrotic kidney in autosomal-dominant polycystic kidney disease patients: a pilot study.

Silvia Lai, Adolfo Marco Perrotta, Valeria Panebianco, Sandro Mazzaferro, Paolo Menè, Chiara Pellicano, Francesca Tinti, Maurizio Muscaritoli, Rosario Cianci, Antonietta Gigante

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In one paragraph

Article in International urology and nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Silvia LaiDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy. silvia.lai@uniroma1.it.ORCID http://orcid.org/0000-0002-7199-2954
Adolfo Marco PerrottaDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Valeria PanebiancoDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Sandro MazzaferroDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Paolo MenèDepartment of Clinical Sciences, Division of Nephrology, University of Rome La Sapienza, Sant'Andrea University Hospital, Rome, Italy.
Chiara PellicanoDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Francesca TintiDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Maurizio MuscaritoliDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Rosario CianciDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Antonietta GiganteDepartment of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Viale Dell'Università 37, 00185, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRenin-angiotensin system hyperactivation in autosomal-dominant polycystic kidney disease (ADPKD) patients leads to early hypertension. Cystic enlargement probably causes parenchymal hypoxia, renin secretion, and endothelial dysfunction. Sympathetic and parasympathetic balance is altered in this condition, especially during the night, also affecting blood pressure circadian rhythm. Aim of this study was to evaluate sympathetic/parasympathetic balance using heart rate variability (HRV) parameters and find a correlation between HRV and renal damage progression, as total kidney volume enlargement, in ADPKD patients.

methodsSixteen adult ADPKD patients were enrolled in the study. Eleven patients (68.8%) were male, and the median age was 42 years (IQR 36-47.5). HRV parameters were calculated using 24 h-ECG Holter. A kidney magnetic resonance imaging (MRI) scan 3 Tesla was performed to evaluate total kidney volume (TKV) and total fibrotic volume (TFV).

resultsA statistically significant positive linear correlation was observed between length of kidneys and frequency domain parameters as low frequency (LF) (r = 0.595, p < 0.05) and LFday (r = 0.587, p < 0.05). Moreover, a statistically significant positive linear correlation exists between high frequency (HF) and TFV (r = 0.804, p < 0.01) or height-adjusted (ha) TFV (r = 0.801, p < 0.01). Finally, we found a statistically significant positive linear correlation between HFnight and TKV (r = 0.608, p < 0.05), ha-TKV (r = 0.685, p < 0.01), TFV (r = 0.594, p < 0.05), and ha-TFV (r = 0.615, p < 0.05).

conclusionWe suppose that the increase in TKV and TFV could lead to a parasympathetic tone hyperactivation, probably in response to hypoxic stress and vasoconstriction due to cystic enlargement.

Indexed as

Polycystic Kidney, Autosomal DominantAdultDisease ProgressionFemaleFibrosisGlomerular Filtration RateHumansHypertrophyKidneyMagnetic Resonance ImagingMalePilot ProjectsAutosomal-dominant polycystic kidney diseaseHeart rate variabilityRenin–angiotensin–aldosterone systemTotal fibrotic volumeTotal kidney volume

Identifiers

PMID37043156
PMCPMC10611859
OpenAlexW4365136238

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.