Evidence map›Paper›PMID 37043058›Full record

ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2023

Chromosome-length genome assemblies and cytogenomic analyses of pangolins reveal remarkable chromosome counts and plasticity.

Marlys L Houck, Klaus-Peter Koepfli, Taylor Hains, Ruqayya Khan, Suellen J Charter, Julie A Fronczek, Ann C Misuraca, Sergei Kliver, Polina L Perelman, Violetta Beklemisheva and 23 more

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In one paragraph

Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Genomic analysis reveals a cryptic pangolin species.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 15 institutions in 7 countries.

Marlys L HouckConservation Science and Wildlife Health, San Diego Zoo Wildlife Alliance, Escondido, CA, 92027, USA. mhouck@sdzwa.org.
Klaus-Peter KoepfliSmithsonian-Mason School of Conservation, George Mason University, Front Royal, VA, 22630, USA. kkoepfli@gmu.edu.
Taylor HainsCommittee On Evolutionary Biology, University of Chicago, Chicago, IL, 60637, USA.
Ruqayya KhanThe Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Suellen J CharterConservation Science and Wildlife Health, San Diego Zoo Wildlife Alliance, Escondido, CA, 92027, USA.
Julie A FronczekConservation Science and Wildlife Health, San Diego Zoo Wildlife Alliance, Escondido, CA, 92027, USA.
Ann C MisuracaConservation Science and Wildlife Health, San Diego Zoo Wildlife Alliance, Escondido, CA, 92027, USA.
Sergei KliverCenter for Evolutionary Hologenomics, The Globe Institute, The University of Copenhagen, 5A, Oester Farimagsgade, 1353, Copenhagen, Denmark.
Polina L PerelmanDepartment of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia.
Violetta BeklemishevaDepartment of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia.
Alexander GraphodatskyDepartment of the Diversity and Evolution of Genomes, Institute of Molecular and Cellular Biology SB RAS, 630090, Novosibirsk, Russia.
Shu-Jin LuoThe State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences (CLS), School of Life Sciences, Peking University, Beijing, 100871, China.
Stephen J O'BrienLaboratory of Genomic Diversity, Computer Technologies Laboratory, ITMO University, 197101, St. Petersburg, Russia.
Norman T-L LimNatural Sciences and Science Education, National Institute of Education, Nanyang Technological University, Singapore, 637616, Singapore.
Jason S C ChinTaipei Zoo, No. 30 Sec. 2 Xinguang Rd., Taipei, 11656, Taiwan.
Vanessa GuerraDepartment of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada.
Gaik TamazianCentre for Computational Biology, Peter the Great Saint Petersburg Polytechnic University, St. Petersburg, 195251, Russia.
Arina OmerThe Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
David WeiszThe Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Kenneth KaemmererPittsburgh Zoo & Aquarium, PA, 15206, Pittsburgh, USA.
Ginger SturgeonPittsburgh Zoo & Aquarium, PA, 15206, Pittsburgh, USA.
Joseph GaspardPittsburgh Zoo & Aquarium, PA, 15206, Pittsburgh, USA.
Alicia HahnPittsburgh Zoo & Aquarium, PA, 15206, Pittsburgh, USA.
Mark McDonoughPittsburgh Zoo & Aquarium, PA, 15206, Pittsburgh, USA.
Isabel Garcia-TreviñoCenter for Conservation and Research, San Antonio Zoo, San Antonio, TX, 78212, USA.
Jordan GentryCenter for Conservation and Research, San Antonio Zoo, San Antonio, TX, 78212, USA.
Rob L CokeCenter for Conservation and Research, San Antonio Zoo, San Antonio, TX, 78212, USA.
Jan E JaneckaDepartment of Biological Sciences, Bayer School of Natural and Environmental Sciences, Duquesne University, Pittsburgh, PA, 15282, USA.
Ryan J HarriganCenter for Tropical Research, Institute of the Environment and Sustainability, University of California, Los Angeles, CA, 90095, USA.
Jen TinsmanCenter for Tropical Research, Institute of the Environment and Sustainability, University of California, Los Angeles, CA, 90095, USA.
Thomas B SmithCenter for Tropical Research, Institute of the Environment and Sustainability, University of California, Los Angeles, CA, 90095, USA.
Erez Lieberman AidenThe Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Olga DudchenkoThe Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA. Olga.Dudchenko@bcm.edu.
Baylor College of Medicine · USInstitute of Molecular and Cell Biology · RUUniversity of California, Los Angeles · USBroad Institute · USCenter for Theoretical Biological Physics · USDuquesne University · USGeorge Mason University · USNanyang Technological University · SGNova Southeastern University · USPeking University · CNPeter the Great St. Petersburg Polytechnic University · RUSimon Fraser University · CATaipei Hospital · TWUniversity of Chicago · USUniversity of Copenhagen · DK

Funding

Center for Genome ImagingRM1HG011016 · NHGRI · HARVARD MEDICAL SCHOOL · PI WU, CHAO-TING · 2021 to 2025
$12.2M
GENOME WIDE MAPPING OF LOOPS USING IN SITU HI-CUM1HG009375 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2017 to 2021
$4.7M
NHGRI NIH HHS RM1 HG011016NHGRI NIH HHS UM1 HG009375
6 · The paper itself

Abstract

We report the first chromosome-length genome assemblies for three species in the mammalian order Pholidota: the white-bellied, Chinese, and Sunda pangolins. Surprisingly, we observe extraordinary karyotypic plasticity within this order and, in female white-bellied pangolins, the largest number of chromosomes reported in a Laurasiatherian mammal: 2n = 114. We perform the first karyotype analysis of an African pangolin and report a Y-autosome fusion in white-bellied pangolins, resulting in 2n = 113 for males. We employ a novel strategy to confirm the fusion and identify the autosome involved by finding the pseudoautosomal region (PAR) in the female genome assembly and analyzing the 3D contact frequency between PAR sequences and the rest of the genome in male and female white-bellied pangolins. Analyses of genetic variability show that white-bellied pangolins have intermediate levels of genome-wide heterozygosity relative to Chinese and Sunda pangolins, consistent with two moderate declines of historical effective population size. Our results reveal a remarkable feature of pangolin genome biology and highlight the need for further studies of these unique and endangered mammals.

Indexed as

MammalsPangolinsAnimalsChromosomesFemaleGenomeMalechromosome numbergenome assemblykaryotypePhataginus tricuspisPholidota

Identifiers

PMID37043058
OpenAlexW4365134808

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.