Evidence map›Paper›PMID 37042761›Full record

ArticlemBio2023

Impact of Polymicrobial Infection on Fitness of Streptococcus gordonii

Satya D Pandey, John D Perpich, Kendall S Stocke, Jillian M Mansfield, Yuichiro Kikuchi, Lan Yakoumatos, Artur Muszyński, Parastoo Azadi, Hervé Tettelin, Marvin Whiteley and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Satya D PandeyDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
John D PerpichDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Kendall S StockeDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Jillian M MansfieldDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, USA.
Yuichiro KikuchiDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Lan YakoumatosDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Artur MuszyńskiDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Parastoo AzadiDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Hervé TettelinDepartment of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Marvin WhiteleySchool of Biological Sciences, Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA.ORCID 0000-0002-4933-9983
Silvia M UriarteDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Juhi BagaitkarCenter for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, Ohio, USA.
Margaret VickermanDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, USA.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.ORCID 0000-0002-3147-5039
University of Louisville · USUniversity at Buffalo, State University of New York · USUniversity of Georgia · USGeorgia Institute of Technology · USNationwide Children's Hospital · USUniversity of Maryland, Baltimore · US

Funding

National Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2M
Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
Folate-Modulated Virulence of Porphyromonas gingivalisF32DE031493 · NIDCR · UNIVERSITY OF LOUISVILLE · PI STOCKE, KENDALL · 2021 to 2023
$208k
NIDCR NIH HHS F32 DE031493NIDCR NIH HHS R01 DE023193NIGMS NIH HHS R24 GM137782
6 · The paper itself

Abstract

Pathogenic microbial ecosystems are often polymicrobial, and interbacterial interactions drive emergent properties of these communities. In the oral cavity, Streptococcus gordonii is a foundational species in the development of plaque biofilms, which can contribute to periodontal disease and, after gaining access to the bloodstream, target remote sites such as heart valves. Here, we used a transposon sequencing (Tn-Seq) library of S. gordonii to identify genes that influence fitness in a murine abscess model, both as a monoinfection and as a coinfection with an oral partner species, Porphyromonas gingivalis. In the context of a monoinfection, conditionally essential genes were widely distributed among functional pathways. Coinfection with P. gingivalis almost completely changed the nature of

Indexed as

CoinfectionStreptococcus gordoniiAnimalsBiofilmsEcosystemMiceMouthneutrophil killingpolymicrobial synergyreceptor polysaccharide

Identifiers

PMID37042761
PMCPMC10294625
OpenAlexW4365134765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.