Evidence map›Paper›PMID 37042449›Full record

ArticleJournal of applied clinical medical physics2023

Self-configuring nnU-Net for automatic delineation of the organs at risk and target in high-dose rate cervical brachytherapy, a low/middle-income country's experience.

Didier Duprez, Christoph Trauernicht, Hannah Simonds, O'Brian Williams

Open access · goldAbstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Systematic review of artificial intelligence in brachytherapy.Journal of contemporary brachytherapy · 2026
    Review
  5. Review
  6. Article
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  8. A review of artificial intelligence in brachytherapy.Journal of applied clinical medical physics · 2025
    Review
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Didier DuprezDivision of Medical Physics, Stellenbosch University, Tygerberg Academic Hospital, Cape Town, South Africa.
Christoph TrauernichtDivision of Medical Physics, Stellenbosch University, Tygerberg Academic Hospital, Cape Town, South Africa.
Hannah SimondsDepartment of Oncology, University Hospitals Plymouth NHS trust, Plymouth, UK.
O'Brian WilliamsDivision of Radiation Oncology, Stellenbosch University, Tygerberg Academic Hospital, Cape Town, South Africa.
Tygerberg Hospital · ZAStellenbosch University · ZAUniversity Hospitals Plymouth NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe high-dose rate (HDR) brachytherapy treatment planning workflow for cervical cancer is a labor-intensive, time-consuming, and expertise-driven process. These issues are amplified in low/middle-income countries with large deficits in experienced healthcare professionals. Automation has the ability to substantially reduce bottlenecks in the planning process but often require a high level of expertise to develop. PURPOSE: To implement the out of the box self-configuring nnU-Net package for the auto-segmentation of the organs at risk (OARs) and high-risk CTV (HR CTV) for Ring-Tandem (R-T) HDR cervical brachytherapy treatment planning.

methodsThe computed tomography (CT) scans of 100 previously treated patients were used to train and test three different nnU-Net configurations (2D, 3DFR, and 3DCasc). The performance of the models was evaluated by calculating the Sørensen-dice similarity coefficient, Hausdorff distance (HD), 95

resultsThe mean DSC, HD, HD95, MSD and precision scores for our best performing model (3DFR) were 0.92/7.5 mm/3.0 mm/ 0.8 mm/0.91 for the bladder, 0.84/13.8 mm/5.3 mm/1.4 mm/0.84 for the rectum, and 0.81/8.5 mm/6.0 mm/2.2 mm/0.80 for the HR CTV. Mean dose differences (D

conclusionOur best performing model (3DFR) provided fast accurate auto generated OARs and HR CTV contours with a large clinical acceptance rate.

Indexed as

BrachytherapyUterine Cervical NeoplasmsFemaleHumansOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRectumcervical cancerdeep learninghigh-dose rate brachytherapysegmentation

Identifiers

PMID37042449
PMCPMC10402684
OpenAlexW4365136088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.