Evidence map›Paper›PMID 37042131›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2023

[Read-through circular RNA rt-circ-HS promotes hypoxia inducible factor 1α expression and renal carcinoma cell proliferation, migration and invasiveness].

Y Y Xu, Z Z Su, L M Zheng, M N Zhang, J Y Tan, Y L Yang, M X Zhang, M Xu, N Chen, X Q Chen and 1 more

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Y Y XuDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Z Z SuDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
L M ZhengDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
M N ZhangDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
J Y TanDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Y L YangDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
M X ZhangDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
M XuDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
N ChenDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
X Q ChenDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Q ZhouDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify and characterize read-through RNAs and read-through circular RNAs (rt-circ-HS) derived from transcriptional read-through hypoxia inducible factor 1α (

methodsReverse transcription-polymerase chain reaction (RT-PCR) and Sanger sequencing were used to examine expression of read-through RNAs HIF1α-SNAPC1 and rt-circ-HS in different tumor cells. Tissue microarrays of 437 different types of renal cell carcinoma (RCC) were constructed, and chromogenic

resultsWe discovered a novel 1 144 nt rt-circ-HS, which was derived from read-through RNA HIF1α-SNAPC1 and consisted of

conclusionThe novel rt-circ-HS is highly expressed in different types of RCCs and acts as a competitive endogenous inhibitor of miR-539 to promote expression of its parental gene

Indexed as

Carcinoma, Renal CellHypoxia-Inducible Factor 1, alpha SubunitKidney NeoplasmsMicroRNAsRNA, CircularCell ProliferationHumansHypoxiaNeoplasm InvasivenessRNA, Small InterferingHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsMIRN539 microRNA, humanRNA, CircularRNA, Small InterferingHypoxia inducible factor 1αmicroRNA 539Read-through circular RNA HIF1α-SNAPC1Renal cell carcinomaSmall nuclear RNA activating complex polypeptide 1

Identifiers

PMID37042131
PMCPMC10091263
OpenAlexW4365135070

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.