Evidence map›Paper›PMID 37042041›Full record

ArticleJournal of dental research2023

Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries.

D Kahharova, V Y Pappalardo, M J Buijs, R X de Menezes, M Peters, R Jackson, A T Hara, G Eckert, B Katz, M A Keels and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of dental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Effects of Oral Probiotics onDentistry journal · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Interactions between non-Journal of oral microbiology · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

D KahharovaDepartment of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-2430-9227
V Y PappalardoDepartment of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
M J BuijsDepartment of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
R X de MenezesBiostatistics Centre, Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
M PetersDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2050-3978
R JacksonDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University, Indianapolis, IN, USA.
A T HaraDepartment of Cariology, Operative Dentistry and Dental Public Health, Indiana University, Indianapolis, IN, USA.ORCID 0000-0001-9822-6064
G EckertDepartment of Biostatistics and Health Data Science, Indiana University, Indianapolis, IN, USA.ORCID 0000-0001-7798-7155
B KatzDepartment of Biostatistics and Health Data Science, Indiana University, Indianapolis, IN, USA.
M A KeelsDepartment of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
S M LevyDepartment of Preventive and Community Dentistry, College of Dentistry and Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
E ZauraDepartment of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
B W BrandtDepartment of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
M FontanaDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2357-7534
Academic Center for Dentistry Amsterdam · NLIndiana University – Purdue University Indianapolis · USUniversity of Michigan · USDuke University · USThe Netherlands Cancer Institute · NLUniversity of Iowa · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Predicting Caries Risk in Underserved Toddlers in Primary Healthcare SettingsU01DE021412 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Margherita R Fontana · 2011 to 2026
$24.0M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
Indiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6M
NCATS NIH HHS UL1 TR000006NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000442NIDCR NIH HHS U01 DE021412
6 · The paper itself

Abstract

Dental caries lesions are a clinical manifestation of disease, preceded by microbial dysbiosis, which is poorly characterized and thought to be associated with saccharolytic taxa. Here, we assessed the associations between the oral microbiome of children and various caries risk factors such as demographics and behavioral and clinical data across early childhood and characterized over time the salivary and dental plaque microbiome of children before clinical diagnosis of caries lesions. Children (

Indexed as

Dental CariesDental PlaqueMicrobiotaChildChild, PreschoolDysbiosisHumansRNA, Ribosomal, 16SSalivaRNA, Ribosomal, 16S16S rRNAantibioticschilddental cariesdental plaquesaliva

Identifiers

PMID37042041
PMCPMC10288166
OpenAlexW4365135593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.