ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2023
Chemical Constituents and Antidiabetic Activity of Dichloromethane Extract from
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Characterizing the Antihyperglycemic Activity and Underlying Mechanisms of the Aqueous Extract of the Leaves fromMolecules (Basel, Switzerland) · 2026Article
- Ethyl acetate extract ofFrontiers in pharmacology · 2025Article
- Ethnobotanical assessment of antidiabetic medicinal plants in District Karak, Pakistan.BMC complementary medicine and therapies · 2024Article
- A review ofAmerican journal of translational research · 2024Review
- Alleviative Effect ofPlants (Basel, Switzerland) · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Purpose: To evaluate the dichloromethane extract of Material and Methods: The antidiabetic activity of dichloromethane extract of Results: FCL extract lowers blood glucose and improves blood lipids and the pancreatic β-cell also tend to recover whether the psoralen is removed or not. Meanwhile, three coumarins except psoralen were isolated from dichloromethane extract: 3,4-dihydropsoralen, umbelliferone and 7-hydroxyl-6-methylcoumarin. Psoralen and umbelliferone promoted glucose uptake in HepG2 cells. Discussion and Conclusion: In vivo experiments, dichloromethane extract of FCL has potential antidiabetic activity, mainly by lowering blood glucose, improving blood lipids, glucose tolerance and repairing pancreatic islet damage, which justifies its use in the treatment of diabetes in Spanish folklore. Additionally, in vitro experiments, psoralen and umbelliferone demonstrated substantial glucose-lowering activity.
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