Evidence map›Paper›PMID 37041721›Full record

ArticleCancer medicine2023

CircPTPRA promotes the progression of pancreatic ductal adenocarcinoma via the miR-140-5p/LMNB1 axis.

Wen Fu, Xianxing Wang, Jifeng Xiang, Shengkai Chen, Renpei Xia, Fuming Xie, Bojing Chi, Fanbo Qin, Zhuo Li, Li Mou and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Circular RNAs Variously Participate in Coronary Atherogenesis.Current issues in molecular biology · 2023
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Wen FuChongqing Medical University, Chongqing, 400016, China.ORCID 0000-0002-9724-2756
Xianxing WangDepartment of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, 401147, China.
Jifeng XiangDepartment of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, 401147, China.
Shengkai ChenDepartment of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, 401147, China.
Renpei XiaDepartment of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing, 401147, China.
Fuming XieChongqing Medical University, Chongqing, 400016, China.
Bojing ChiChinese Academy of Sciences, Beijing, 101400, China.
Fanbo QinChongqing Medical University, Chongqing, 400016, China.
Zhuo LiChinese Academy of Sciences, Beijing, 101400, China.
Li MouNHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, 400020, China.
Chuanming XieKey Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Huaizhi WangChongqing Medical University, Chongqing, 400016, China.
First People's Hospital of Chongqing · CNChinese Academy of Social Sciences · CNChongqing Medical University · CNArmy Medical University · CNChongqing Population and Family Planning Science and Technology Research Institute · CNChongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowing evidences suggest that circular RNAs (circRNAs) are important factors in cancer progression. Nevertheless, the role of circRNAs in the progression of pancreatic ductal adenocarcinoma (PDAC) remains unclear.

methodsCircPTPRA was identified based on our previous circRNA array data analysis. Wound healing, transwell, and EdU assays were performed to investigate the effect of circPTPRA on the migration, invasion, and proliferation of PDAC cells in vitro. RNA pull-down, fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP), and dual-luciferase reporter assays were conducted to verify the binding of circPTPRA with miR-140-5p. Subcutaneous xenograft model was constructed for in vivo experiment.

resultsCircPTPRA was significantly upregulated in PDAC tissues and cells compared to normal controls. Moreover, circPTPRA overexpression was positively correlated with lymph node invasion and worse prognosis in PDAC patients. In addition, overexpression of circPTPRA promoted PDAC migration, invasion, proliferation, and epithelial-mesenchymal transition (EMT) in vitro and in vivo. Mechanistically, circPTPRA upregulates LaminB1 (LMNB1) expression by sponging miR-140-5p and ultimately promotes the progression of PDAC.

conclusionsThis study revealed that circPTPRA plays an important role in the progression of PDAC by sponging miR-140-5p. It can be explored as a potential prognostic marker and therapeutic target for PDAC.

Indexed as

Carcinoma, Pancreatic DuctalMicroRNAsPancreatic NeoplasmsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansIn Situ Hybridization, FluorescenceRNA, CircularMicroRNAsMirn140 microRNA, humanRNA, CircularCircPTPRAepithelial-mesenchymal transitionLMNB1MiR-140-5ppancreatic ductal adenocarcinoma

Identifiers

PMID37041721
PMCPMC10242365
OpenAlexW4365135793

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.