ArticleGenome biology2023
PhyloMed: a phylogeny-based test of mediation effect in microbiome.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Bibliometric analysis of research trends and hotspots on the microbial mediation effects.Antonie van Leeuwenhoek · 2026Article
- Distinct microbial mediators link diet to inflammation in Crohn's disease and ulcerative colitis.Gut · 2026Article
- Microbiome mediation analysis: methods, assumptions, and practical considerations.Frontiers in cellular and infection microbiology · 2026Review
- TCVS: tree-guided compositional variable selection analysis of microbiome data.Bioinformatics (Oxford, England) · 2025Article
- Multimedia: multimodal mediation analysis of microbiome data.Microbiology spectrum · 2025Article
- Constructing phylogenetic trees for microbiome data analysis: A mini-review.Computational and structural biotechnology journal · 2024Review
- Assessing the effect of model specification and prior sensitivity on Bayesian tests of temporal signal.PLoS computational biology · 2024Article
- multimedia: Multimodal Mediation Analysis of Microbiome Data.bioRxiv : the preprint server for biology · 2024Article
- DeepPL: A deep-learning-based tool for the prediction of bacteriophage lifecycle.PLoS computational biology · 2024Article
- Specialty grand challenge: how can we use integrative approaches to understand microbial community dynamics?Frontiers in systems biology · 2024Article
- PhyloMed: a phylogeny-based test of mediation effect in microbiome.Genome biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Microbiome data from sequencing experiments contain the relative abundance of a large number of microbial taxa with their evolutionary relationships represented by a phylogenetic tree. The compositional and high-dimensional nature of the microbiome mediator challenges the validity of standard mediation analyses. We propose a phylogeny-based mediation analysis method called PhyloMed to address this challenge. Unlike existing methods that directly identify individual mediating taxa, PhyloMed discovers mediation signals by analyzing subcompositions defined on the phylogenic tree. PhyloMed produces well-calibrated mediation test p-values and yields substantially higher discovery power than existing methods.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.