ArticleTheory in biosciences = Theorie in den Biowissenschaften2023
A computational investigation of cis-gene regulation in evolution.
Article in Theory in biosciences = Theorie in den Biowissenschaften, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors at 2 institutions in 2 countries.
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Abstract
In biological processes involving gene networks, genes regulate other genes that determine the phenotypic traits. Gene regulation plays an important role in evolutionary dynamics. In a genetic algorithm, a trans-gene regulatory mechanism was shown to speed up adaptation and evolution. Here, we examine the effect of cis-gene regulation on an adaptive system. The model is haploid. A chromosome is partitioned into regulatory loci and structural loci. The regulatory genes regulate the expression and functioning of structural genes via the cis-elements in a probabilistic manner. In the simulation, the change in the allele frequency, the mean population fitness and the efficiency of phenotypic selection are monitored. Cis-gene regulation increases adaption and accelerates the evolutionary process in comparison with the case involving absence of gene regulation. Some special features of the simulation results are as follows. A low ratio of regulatory loci and structural loci gives higher adaptation for fixed total number of loci. Plasticity is advantageous beyond a threshold value. Adaptation is better for large number of total loci when the ratio of regulatory loci to structural loci is one. However, it reaches a saturation beyond which the increase in the total loci is not advantageous. Efficiency of the phenotypic selection is higher for larger value of the initial plasticity.
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