Evidence map›Paper›PMID 37041128›Full record

ArticleBlood cancer journal2023

TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms.

Mithun Vinod Shah, Elizabeth Ngoc Hoa Tran, Syed Shah, Rakchha Chhetri, Anmol Baranwal, Dariusz Ladon, Carl Shultz, Aref Al-Kali, Anna L Brown, Dong Chen and 12 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Blood cancer journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. MedComm · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 2 countries.

Mithun Vinod ShahDivision of Hematology, Mayo Clinic, Rochester, MN, USA. shah.mithun@mayo.edu.ORCID 0000-0002-5359-336X
Elizabeth Ngoc Hoa TranPrecision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.ORCID 0000-0003-1644-2287
Syed ShahDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Rakchha ChhetriPrecision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
Anmol BaranwalDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3432-0489
Dariusz LadonGenetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia.
Carl ShultzDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Aref Al-KaliDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Anna L BrownUniversity of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-9023-0138
Dong ChenDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Hamish S ScottUniversity of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-5813-631X
Patricia GreippDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5536-9011
Daniel ThomasPrecision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
Hassan B AlkhateebDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Deepak SinghalPrecision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
Naseema GangatDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-9104-6172
Sharad KumarUniversity of Adelaide, Adelaide, SA, Australia.ORCID 0000-0001-7126-9814
Mrinal M PatnaikDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-6998-662X
Christopher N HahnUniversity of Adelaide, Adelaide, SA, Australia.ORCID 0000-0001-5105-2554
Chung Hoow KokPrecision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.ORCID 0000-0002-3181-7852
Ayalew TefferiDivision of Hematology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-4605-3821
Devendra K HiwasePrecision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia. devendra.hiwase@sa.gov.au.ORCID 0000-0002-6666-3056
Mayo Clinic in Arizona · USSouth Australia Pathology · AURoyal Adelaide Hospital · AUSouth Australian Health and Medical Research Institute · AUMayo Clinic · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
NCI NIH HHS P30 CA015083
6 · The paper itself

Abstract

Revised diagnostic criteria for myeloid neoplasms (MN) issued by the International Consensus Classification (ICC) and the World Health Organization (WHO) recommended major change pertaining to TP53-mutated (TP53

Indexed as

Gene FrequencyLeukemia, Myeloid, AcuteMyelodysplastic SyndromesTumor Suppressor Protein p53AgedAllelesFemaleHumansMaleMiddle AgedMutationPrognosisRetrospective StudiesTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID37041128
PMCPMC10090194
OpenAlexW4364379042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.