Evidence map›Paper›PMID 37041032›Full record

ArticleRNA (New York, N.Y.)2023

Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the

Mary Kay Thompson, Arianna Ceccarelli, David Ish-Horowicz, Ilan Davis

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. The mRNA stability factor Khd4 defines a specific mRNA regulon for membrane trafficking in the pathogenProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Mary Kay ThompsonDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0002-4947-6048
Arianna CeccarelliMathematical Institute, University of Oxford, Oxford OX1 3LB, United Kingdom.ORCID 0000-0002-9598-8845
David Ish-HorowiczDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0001-5684-7129
Ilan DavisDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom ilan.davis@bioch.ox.ac.uk.ORCID 0000-0002-5385-3053
University of Oxford · GB

Funding

Wellcome Trust 209412/Z/17/Z
6 · The paper itself

Abstract

The level of each RNA species depends on the balance between its rates of production and decay. Although previous studies have measured RNA decay across the genome in tissue culture and single-celled organisms, few experiments have been performed in intact complex tissues and organs. It is therefore unclear whether the determinants of RNA decay found in cultured cells are preserved in an intact tissue, and whether they differ between neighboring cell types and are regulated during development. To address these questions, we measured RNA synthesis and decay rates genome wide via metabolic labeling of whole cultured

Indexed as

DrosophilaTranscription FactorsAnimalsBrainLarvaRNA, MessengerRNA StabilityRNA, MessengerTranscription Factors4-thiouridinebrain developmentDrosophilaRNA decay

Identifiers

PMID37041032
PMCPMC10275270
OpenAlexW4364379242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.