Evidence map›Paper›PMID 37041031›Full record

ArticleRNA (New York, N.Y.)2023

Initiation of translation on nedicistrovirus and related intergenic region IRESs by their factor-independent binding to the P site of 80S ribosomes.

Anna Miścicka, Kristen Lu, Irina S Abaeva, Tatyana V Pestova, Christopher U T Hellen

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. RNAViruses · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Ins and outs of IRES elements: function and significance.Biochemical Society transactions · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna Miścicka *Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203, USA.
Kristen Lu *Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203, USA.
Irina S AbaevaDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203, USA.
Tatyana V PestovaDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203, USA.ORCID 0000-0003-3543-256X
Christopher U T HellenDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York 11203, USA christopher.hellen@downstate.edu.ORCID 0000-0002-3982-2090

Funding

Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality controlR35GM122602 · NIGMS · SUNY DOWNSTATE MEDICAL CENTER · PI TATYANA V PESTOVA · 2017 to 2026
$4.8M
Non-canonical mechanisms of translation of viral mRNAsR01AI123406 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI HELLEN, CHRISTOPHER ULRICH TRISTRAM · 2016 to 2020
$3.1M
Alternative mechanisms of different stages in eukaryotic translationR01GM097014 · NIGMS · SUNY DOWNSTATE MEDICAL CENTER · PI HELLEN, CHRISTOPHER ULRICH TRISTRAM · 2012 to 2022
$2.6M
NIAID NIH HHS R01 AI123406NIGMS NIH HHS R01 GM097014NIGMS NIH HHS R35 GM122602
6 · The paper itself

Abstract

Initiation of translation on many viral mRNAs occurs by noncanonical mechanisms that involve 5' end-independent binding of ribosomes to an internal ribosome entry site (IRES). The ∼190-nt-long intergenic region (IGR) IRES of dicistroviruses such as cricket paralysis virus (CrPV) initiates translation without Met-tRNA

Indexed as

Internal Ribosome Entry SitesRibosomesDNA, IntergenicPeptide Initiation FactorsProtein BiosynthesisRNA, TransferRNA, ViralDNA, IntergenicInternal Ribosome Entry SitesPeptide Initiation FactorsRNA, TransferRNA, ViralAntarctic picorna-like virus 1dicistrovirusIRESnedicistrovirusribosometranslation initiation

Identifiers

PMID37041031
PMCPMC10275262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.