Evidence map›Paper›PMID 37040735›Full record

ReviewAnnual review of biomedical data science2023

Computational Methods for Single-Cell Proteomics.

Sophia M Guldberg, Trine Line Hauge Okholm, Elizabeth E McCarthy, Matthew H Spitzer

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of biomedical data science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Sophia M GuldbergDepartment of Otolaryngology-Head and Neck Surgery and Department of Microbiology and Immunology, University of California, San Francisco, California, USA; email: matthew.spitzer@ucsf.edu.
Trine Line Hauge OkholmDepartment of Otolaryngology-Head and Neck Surgery and Department of Microbiology and Immunology, University of California, San Francisco, California, USA; email: matthew.spitzer@ucsf.edu.
Elizabeth E McCarthyDepartment of Otolaryngology-Head and Neck Surgery and Department of Microbiology and Immunology, University of California, San Francisco, California, USA; email: matthew.spitzer@ucsf.edu.
Matthew H SpitzerDepartment of Otolaryngology-Head and Neck Surgery and Department of Microbiology and Immunology, University of California, San Francisco, California, USA; email: matthew.spitzer@ucsf.edu.
Chan Zuckerberg Initiative (United States) · USGladstone Institutes · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, San Francisco · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Immune determinants of progression from Oral Epithelial Dysplasia to Oral Squamous Cell Carcinoma by precision multiplexed imagingR01DE032033 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Spitzer · 2022 to 2026
$3.8M
Discovery of myeloid immune features predictive of response to cancer immunotherapy in prostate cancerF30CA257291 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCARTHY, ELIZABETH · 2021 to 2024
$184k
Determining the role of AIRE and AIRE-expressing tumor associated macrophages in tumor growth and immunityF31CA271748 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GULDBERG, SOPHIA · 2023 to 2024
$81k
NCI NIH HHS F30 CA257291NCI NIH HHS F31 CA271748NIDCR NIH HHS R01 DE032033NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Advances in single-cell proteomics technologies have resulted in high-dimensional datasets comprising millions of cells that are capable of answering key questions about biology and disease. The advent of these technologies has prompted the development of computational tools to process and visualize the complex data. In this review, we outline the steps of single-cell and spatial proteomics analysis pipelines. In addition to describing available methods, we highlight benchmarking studies that have identified advantages and pitfalls of the currently available computational toolkits. As these technologies continue to advance, robust analysis tools should be developed in tandem to take full advantage of the potential biological insights provided by these data.

Indexed as

Computational BiologyProteomicsclusteringcomputational methodsdata analysismass cytometryspatial proteomicstrajectory inference

Identifiers

PMID37040735
PMCPMC10621466
OpenAlexW4364357034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.