Evidence map›Paper›PMID 37040598›Full record

ArticleJournal of intellectual disabilities : JOID2024

Does Employment Complexity Promote Healthy Cognitive Aging in Down Syndrome?

Brianna Piro-Gambetti, Emily K Schworer, Benjamin Handen, Masha Glukhovskaya, Sigan L Hartley

Open access · greenAbstract read
In one paragraph

Article in Journal of intellectual disabilities : JOID, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome.Journal of applied research in intellectual disabilities : JARID · 2025
    Article
  3. Resistance and resilience to Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brianna Piro-GambettiWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-3330-441X
Emily K SchworerWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-5309-339X
Benjamin HandenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Masha GlukhovskayaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Sigan L HartleyWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · USUniversity of Pittsburgh · US

Funding

NiAD Supplement WashU Start UpU01AG051406 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONSTANTINO, JOHN N., HANDEN, BENJAMIN L · 2015 to 2019
$21.3M
POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
Lifestyle Risk and Resiliency Factors and Alzheimer’s Disease in Down syndromeR01AG070028 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley, Christy Hom · 2020 to 2026
$4.6M
NIA NIH HHS R01 AG070028NIA NIH HHS U01 AG051406NICHD NIH HHS T32 HD007489NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

Adults with Down syndrome (DS) experience high risk for Alzheimer's disease (AD), but there is variability in the timing of transition from a cognitively stable state to prodromal AD and dementia. The present study examined the association between a modifiable lifestyle factor, employment complexity, and cognitive decline across two time points in adults with DS. Employment complexity, defined as the degree of problem-solving or critical thinking required for employment activities, was operationalized using the Dictionary of Occupational Titles, a system which classifies occupations based on three categories:

Indexed as

Cognitive DysfunctionDown SyndromeEmploymentAdultCognitive AgingFemaleHumansMaleMiddle AgedProblem SolvingAlzheimer’s diseasecognitiondementiadown syndromeemployment

Identifiers

PMID37040598
PMCPMC10564966
OpenAlexW4364377639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.