ArticleAesthetic surgery journal2023
Longevity of Post-Explantation Systemic Symptom Improvement and Potential Etiologies: Findings From the ASERF Systemic Symptoms in Women-Biospecimen Analysis Study: Part 4.
Article in Aesthetic surgery journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Breast Implant Illness: Symptoms, Outcomes with Explantation and Potential Etiologies-A Systematic Review and Meta-analysis.Aesthetic plastic surgery · 2025Pooled it
- Systematic biocompatibility assessment of 4-µm surface silicone implants.Biomaterials and biosystems · 2026Article
- Breast Explant Procedures: Current Opinions and Practices Among Specialist Surgeons in Australia.Aesthetic plastic surgery · 2026Article
- Concerns with the Manuscript: Breast Implant Illness: Symptoms, Outcomes with Explantation and Potential Etiologies-A Systemic Review and Meta-analysis.Aesthetic plastic surgery · 2026Article
- From Hashtags to Health Narratives: A Content Analysis of Breast Implant Illness on TikTok.Aesthetic plastic surgery · 2025Article
- Clinical Management of Breast Implant Illness and Breast Implant-Associated Somatic Symptom Disorder (BIA-SSD): Case Examples of Treatment Options.Plastic and reconstructive surgery. Global open · 2025Article
- Beyond the Posts: Analyzing Breast Implant Illness Discourse With Natural Language Processing and Deep Learning.Aesthetic surgery journal · 2025Article
- Truth or Myth: Is Breast Implant Illness Really an Illness?Plastic and reconstructive surgery. Global open · 2025Article
- The Occurrence of Health Symptoms in General Practice Before and After the Explantation of Cosmetic Breast Implants.Aesthetic surgery journal · 2025Article
- The Diagnosis and Management of Patients With Findings Consistent With a Breast Implant Associated-Somatic Symptom Disorder (BIA-SSD).Plastic and reconstructive surgery. Global open · 2025Article
- Drivers and Barriers of Breast Augmentation Surgery: Multinational Insights.Aesthetic surgery journal. Open forum · 2025Article
- Medical Specialist Care Utilization Prior to the Explantation of Cosmetic Silicone Breast Implants: A Nationwide Retrospective Data Linkage Study.Aesthetic plastic surgery · 2024Article
- Findings Consistent with a Breast Implant-associated Somatic System Disorder (BIA-SSD) Among Patients Self-reporting Breast Implant Illness.Plastic and reconstructive surgery. Global open · 2024Article
- Oxylipins in Breast Implant-Associated Systemic Symptoms.Aesthetic surgery journal · 2024Article
- Correlation Between Medically Diagnosed Anxiety and Depression Disorder and Self-Reported Breast Implant Illness.Aesthetic surgery journal · 2024Article
- Clinical Evaluation of Microbial Communities and Associated Biofilms with Breast Augmentation Failure.Microorganisms · 2024Article
- Biofilm-derived oxylipin 10-HOME-mediated immune response in women with breast implants.The Journal of clinical investigation · 2023Article
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast Implant Illness (BII) describes a variety of symptoms reported by patients with breast implants. Biospecimens data revealed minimal statistical differences between BII and non-BII cohorts. Baseline analysis of PROMIS data demonstrated significant differences between the BII cohort and the 2 control cohorts.
objectivesThis study was designed to determine if patients in the BII cohort obtained any symptom improvement after explantation, whether symptom improvement was related to the type of capsulectomy, and which symptoms improved.
methodsA prospective blinded study enrolled 150 consecutive patients divided equally into 3 cohorts. Baseline demographic data and a systemic symptoms survey, including PROMIS validated questionnaires, were obtained at baseline, 3 to 6 weeks, 6 months, and 1 year.
resultsA total of 150 patients were enrolled between 2019 and 2021. Follow-up at 1 year included 94% of the BII cohort and 77% of non-BII and mastopexy cohorts. At 1 year, 88% of patients showed at least partial symptom improvement, with a reduction of 2 to 20 symptoms. The PROMIS score in the BII cohort decreased at 1 year for anxiety, sleep disturbances, and fatigue. Systemic symptom improvement was noted out to 1 year in the BII cohort regardless of the type of capsulectomy performed.
conclusionsParts 1-3 in this series concluded that there were no consistent differences in biospecimen results between the cohorts. Unlike the data observed in the biospecimen analysis, BII patients had heightened symptoms and poorer PROMIS scores at baseline compared to the control cohorts. The reduction of negative expectations and a potential nocebo effect could contribute to this improvement. LEVEL OF EVIDENCE: 4:
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