Evidence map›Paper›PMID 37040007›Full record

ArticleEndocrine2023

The diagnostic value of a new ultrasonographic method for the measurement of a taller-than-wide shape of benign and malignant thyroid nodules.

Chunxiang Li, Xiaojie Xin, Xiaoqing Wang, Xi Wei, Sheng Zhang

Abstract read
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In one paragraph

Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chunxiang LiDepartment of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key laboratory of Cancer Prevention and Therapy, Tianjin, China.
Xiaojie XinDepartment of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key laboratory of Cancer Prevention and Therapy, Tianjin, China.
Xiaoqing WangDepartment of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key laboratory of Cancer Prevention and Therapy, Tianjin, China.
Xi WeiDepartment of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key laboratory of Cancer Prevention and Therapy, Tianjin, China. weixi@tmu.edu.cn.
Sheng ZhangDepartment of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key laboratory of Cancer Prevention and Therapy, Tianjin, China. zs19620112@126.com.
Tianjin Medical University Cancer Institute and Hospital · CN

Funding

National Natural Science Foundation of China 81771852
6 · The paper itself

Abstract

purposeTo evaluate the diagnostic value of a new ultrasonographic method in the measurement of thyroid nodules with a taller-than-wide (TTW) shape.

methodsA total of 982 thyroid nodules were analysed, 571 of which were malignant thyroid nodules and 411 of which were benign nodules. Nodules were divided into two groups by size: Group A (<1 cm, n = 627) and Group B (≥1 cm, n = 355). The angle between the maximum diameter of each nodule and the horizontal axis was measured by image analysis software. The best cut-off value for distinguishing between benign and malignant thyroid nodules and the diagnostic accuracy of the new ultrasonographic method in the measurement of TTW shapes were determined by receiver operating characteristic (ROC) curve analysis.

resultsThe cut-off value for distinguishing benign and malignant thyroid nodules was 44.5 degrees. The area under the ROC curve (AUC) was 0.849 (95% CI: 0.822~0.875), and the sensitivity and specificity of the diagnosis of malignant thyroid nodules were 86.9% and 84.4%, respectively. Regarding the angle between the maximum diameter and the transverse axis of the thyroid nodules, an angle greater than 45 degrees was a significant indicator of a diagnosis of malignant thyroid nodules. The AUC for distinguishing malignant from benign thyroid nodules with the new ultrasonographic method in the measurement of TTW shapes was higher than that with the first method (FM) in the whole group, Group A and Group B (respectively, 0.849 vs. 0.812, 0.853 vs. 0.808, 0.852 vs. 0.828). The diagnostic sensitivity of a TTW shape measured by the new ultrasonographic method for predicting thyroid malignancy was significantly higher than that measured by the FM in the whole group, Group A and Group B (respectively, 0.858 vs. 0.760, 0.764 vs. 0.669, 0.890 vs. 0.815).

conclusionA TTW shape measured by our new ultrasonographic method showed superior performance for predicting thyroid malignancy.

Indexed as

Thyroid NeoplasmsThyroid NoduleDiagnosis, DifferentialHumansROC CurveSensitivity and SpecificityUltrasonographyAnteroposterior-to-transverse ratioDiagnosisMethodsThyroid nodulesUltrasound

Identifiers

PMID37040007
OpenAlexW4364353714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.