Evidence map›Paper›PMID 37039973›Full record

ArticlePharmacological reports : PR2023

Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery.

Dawid Bursy, Radosław Balwierz, Paweł Groch, Paweł Biernat, Adam Byrski, Katarzyna Kasperkiewicz, Wioletta Ochędzan-Siodłak

Abstract read
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In one paragraph

Article in Pharmacological reports : PR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dawid BursyDepartment of Drug Forms Technology, Faculty of Pharmacy, Wrocław Medical University, Borowska St. 211, 50-556, Wrocław, Poland.ORCID http://orcid.org/0000-0002-5729-6717
Radosław BalwierzInstitute of Chemistry, University of Opole, Oleska St. 48, 45-052, Opole, Poland. radoslaw.balwierz@uni.opole.pl.ORCID http://orcid.org/0000-0002-6173-2702
Paweł GrochInstitute of Chemistry, University of Opole, Oleska St. 48, 45-052, Opole, Poland.ORCID http://orcid.org/0000-0002-4422-0692
Paweł BiernatDepartment of Drug Forms Technology, Faculty of Pharmacy, Wrocław Medical University, Borowska St. 211, 50-556, Wrocław, Poland.ORCID http://orcid.org/0000-0002-5308-4426
Adam ByrskiInstitute of Metallurgy and Materials Science, Polish Academy of Sciences, Reymonta St. 25, 30-059, Cracow, Poland.ORCID http://orcid.org/0000-0003-1152-5964
Katarzyna KasperkiewiczFaculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Jagiellońska St. 28, 40-032, Katowice, Poland.ORCID http://orcid.org/0000-0002-9851-790X
Wioletta Ochędzan-SiodłakInstitute of Chemistry, University of Opole, Oleska St. 48, 45-052, Opole, Poland.ORCID http://orcid.org/0000-0002-8226-4362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNanocarriers for antibacterial drugs became hopeful tools against the increasing resistance of bacteria to antibiotics. This work focuses on a comprehensive study of the applicability and therapeutic suitability of dermal carbopol-based hydrogels containing chloramphenicol carried by various nanoparticles (AuNPs and SiNPs).

methodsThe different forms of carbopol-based drugs for dermal use were obtained. Five different concentrations of chloramphenicol and two types of nanoparticles (silica and gold) in carbopol-based ointments were tested. The influence of different carbopol formulations with nanocarriers on the rheological properties as well as the release profile of active substances and bacteriostatic activity on five reference strains were determined.

resultsThe properties of the obtained hydrogels were compared to a commercial formulation, and finally it was possible to obtain a formulation that allowed improved antimicrobial activity over a commercially available detreomycin ointment while reducing the concentration of the antibiotic.

conclusionThe work indicates that it is possible to reduce the concentration of chloramphenicol by four times while maintaining its bacteriostatic activity, which can improve the patient's safety profile while increasing the effectiveness of the therapy.

Indexed as

Metal NanoparticlesNanoparticlesAnti-Bacterial AgentsChloramphenicolGoldHumansHydrogelsAnti-Bacterial AgentsChloramphenicolGoldHydrogelsAntibioticsBacteriostatic activityCarbopolChloramphenicolDrug deliveryGold nanoparticlesNanoparticlesRheological propertiesSilica nanoparticles

Identifiers

PMID37039973
PMCPMC10227170

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.