ArticleEuropean journal of nuclear medicine and molecular imaging2023
Towards in vivo characterization of thyroid nodules suspicious for malignancy using multispectral optoacoustic tomography.
Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- In-silico investigation into optimal photoacoustic probe design using a digital thyroid phantom.Journal of biomedical optics · 2027Article
- The confounding effects of skin colour in photoacoustic imaging.Nature communications · 2026Article
- Longitudinal three-dimensional photoacoustic imaging reveals hyperoxic perilesional microvasculature associated with keloid recurrence.Photoacoustics · 2026Article
- Feasibility of the photoacoustic detection of haemophilia-related microbleeds: a preclinical study using isolated pig limbs.Thrombosis journal · 2026Article
- Motion score for spectral quality control of optoacoustic-ultrasound data.Scientific reports · 2026Article
- Contrast-enhanced multispectral optoacoustic tomography for the assessment of the gastrointestinal transit in patients with cystic fibrosis.Photoacoustics · 2025Article
- Multispectral optoacoustic tomography of salivary glands in patients with clinically suspected Sjögren's disease: A pilot study.Photoacoustics · 2025Article
- Artifacts in photoacoustic imaging: Origins and mitigations.Photoacoustics · 2025Article
- Review of Linear-Array-Transducer-Based Volumetric Ultrasound Imaging Techniques and Their Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Review on Multispectral Photoacoustic Imaging Using Stimulated Raman Scattering Light Sources.Sensors (Basel, Switzerland) · 2025Review
- Photoacoustic imaging for monitoring radiotherapy treatment response in head and neck tumors.Scientific reports · 2025Article
- A primer on current status and future opportunities of clinical optoacoustic imaging.Npj imaging · 2025Review
- Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies.Biomedical optics express · 2024Article
- Towards molecular imaging-guided intervention theatres in oncology.European journal of nuclear medicine and molecular imaging · 2024Article
- MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer.European journal of nuclear medicine and molecular imaging · 2024Article
- Mini review of photoacoustic clinical imaging: a noninvasive tool for disease diagnosis and treatment evaluation.Journal of biomedical optics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 3 countries.
Funding
Abstract
purposePatient-tailored management of thyroid nodules requires improved risk of malignancy stratification by accurate preoperative nodule assessment, aiming to personalize decisions concerning diagnostics and treatment. Here, we perform an exploratory pilot study to identify possible patterns on multispectral optoacoustic tomography (MSOT) for thyroid malignancy stratification. For the first time, we directly correlate MSOT images with histopathology data on a detailed level.
methodsWe use recently enhanced data processing and image reconstruction methods for MSOT to provide next-level image quality by means of improved spatial resolution and spectral contrast. We examine optoacoustic features in thyroid nodules associated with vascular patterns and correlate these directly with reference histopathology.
resultsOur methods show the ability to resolve blood vessels with diameters of 250 μm at depths of up to 2 cm. The vessel diameters derived on MSOT showed an excellent correlation (R
conclusionWe recommend examining optoacoustic features in addition to chromophore quantification to rank malignancy risk. We present optoacoustic images of thyroid nodules with the highest spatial resolution and spectral contrast to date, directly correlated to histopathology, pushing the clinical translation of MSOT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.