Evidence map›Paper›PMID 37039488›Full record

ArticleCurrent protocols2023

One-Flask Synthesis of Cyclic Diguanosine Monophosphate (c-di-GMP).

Barbara L Gaffney, Roger A Jones

Abstract read
In one paragraph

Article in Current protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Barbara L GaffneyDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey.
Roger A JonesDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey.

Funding

Probing RNA Metal Binding with Specifically Labeled RNAR01GM079760 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI JONES, ROGER A · 2007 to 2010
$1.2M
NIGMS NIH HHS R01 GM079760NIH HHS GM 79760
6 · The paper itself

Abstract

The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) plays a key role in controlling biofilm formation and pathogenic virulence, among many other functions. It has widespread consequences for human health, and current research is actively exploring its molecular mechanisms. The convenient one-flask, gram-scale synthesis of c-di-GMP described here has facilitated these efforts and has been applied to a variety of analogs. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.

Indexed as

Bacterial ProteinsCyclic GMPBacteriaHumansSignal TransductionBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPbacterial signalingc-di-GMPchemical synthesis

Identifiers

PMID37039488
PMCPMC13528268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.