Evidence map›Paper›PMID 37039485›Full record

ArticleExperimental dermatology2023

Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.

Jaewon You, Michael D Reilly, Mahmoud Eljalby, Rohan Bareja, Maftuna Yusupova, Nikki S Vyas, Jakyung Bang, Wanhong Ding, Garrett Desman, Lloyd S Miller and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jaewon YouDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.
Michael D ReillyDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.
Mahmoud EljalbyDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.
Rohan BarejaEnglander Institute of Precision Medicine, Weill Cornell Medicine, New York City, New York, USA.
Maftuna YusupovaDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.
Nikki S VyasDepartments of Pathology and Dermatology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Jakyung BangDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.
Wanhong DingDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.
Garrett DesmanDepartments of Pathology and Dermatology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Lloyd S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Olivier ElementoEnglander Institute of Precision Medicine, Weill Cornell Medicine, New York City, New York, USA.
Richard D GransteinDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.
Jonathan H ZippinDepartment of Dermatology, Weill Cornell Medicine, New York City, New York, USA.ORCID 0000-0002-5882-0189
Cornell University · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USProHealth Care · US

Funding

Mechanisms of cAMP-dependent regulation of melanosome pHR01AR077664 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jonathan Hale Zippin · 2021 to 2026
$3.6M
Uncovering the role of m6A in the melanocyte response to ultraviolet lightR21CA224391 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAFFREY, SAMIE R, ZIPPIN, JONATHAN HALE · 2018 to 2019
$399k
NCI NIH HHS R21 CA224391NIAMS NIH HHS R01 AR077664
6 · The paper itself

Abstract

Cyclic AMP (cAMP) has a key role in psoriasis pathogenesis, as indicated by the therapeutic efficacy of phosphodiesterase inhibitors that prevent the degradation of cAMP. However, whether soluble adenylate cyclase (sAC) (encoded by the ADCY10 gene), which is an important source for cAMP, is involved in Th17 cell-mediated inflammation or could be an alternative therapeutic target in psoriasis is unknown. We have utilized the imiquimod model of murine psoriasiform dermatitis to address this question. Adcy10

Indexed as

Adenylyl CyclasesEczemaPsoriasisAnimalsDisease Models, AnimalImiquimodInflammationMiceSkinTh17 CellsAdcy10 protein, mouseAdenylyl CyclasesImiquimodcAMPimiquimodsoluble adenylyl cyclaseTh17

Identifiers

PMID37039485
PMCPMC10523866
OpenAlexW4364353323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.