Evidence map›Paper›PMID 37039477›Full record

ArticleeLife2023

High-resolution structures with bound Mn

Shamayeeta Ray, Samuel P Berry, Eric A Wilson, Casey H Zhang, Mrinal Shekhar, Abhishek Singharoy, Rachelle Gaudet

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Determinants of metal import and specificity in a bacterial transporter.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Germination ofJournal of bacteriology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. In vitro reconstitution of transition metal transporters.The Journal of biological chemistry · 2024
    Review
  18. Article
  19. Frontiers in oncology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shamayeeta RayDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.ORCID 0000-0001-7906-0572
Samuel P BerryDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Eric A WilsonSchool of Molecular Sciences, Arizona State University, Tempe, United States.
Casey H ZhangDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Mrinal ShekharBroad Institute, Cambridge, United States.
Abhishek SingharoySchool of Molecular Sciences, Arizona State University, Tempe, United States.
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.ORCID 0000-0002-9177-054X
Harvard University · USArizona State University · USBroad Institute · US

Funding

User Training & OutreachP30GM138396 · NIGMS · UCHICAGO ARGONNE, LLC · PI JANET L. SMITH · 2020 to 2026
$34.3M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6M
Mechanism of Divalent Metal Transport by NRamp-Family TransportersR01GM120996 · NIGMS · HARVARD UNIVERSITY · PI GAUDET, RACHELLE · 2017 to 2024
$3.0M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM138396NIGMS NIH HHS R01 GM120996NIGMS NIH HHS T32 GM008313NIH HHS S10 OD012289
6 · The paper itself

Abstract

Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By supporting metal homeostasis, Nramps prevent diseases and disorders related to metal insufficiency or overload. Previous studies revealed that Nramps take on a LeuT fold and identified the metal-binding site. We present high-resolution structures of

Indexed as

CadmiumMetalsIon TransportMembrane Transport ProteinsCadmiumMembrane Transport ProteinsMetalsDeinococcus radioduransE. coliisothermal titration calorimetrymolecular biophysicsNramp transportersstructural biologytransition metal ion transportx-ray crystallography

Identifiers

PMID37039477
PMCPMC10185341
OpenAlexW4364351871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.