ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023
Inflammation and DKK1-induced AKT activation contribute to endothelial dysfunction following NR2F2 loss.
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Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- DNA Methylation-Guided Prediction and Validation of TAAD Molecular Targets.Biochemical genetics · 2026Article
- DKK1 activated the NF-κB pathway by binding with CKAP4 to induce PASMC oxidative stress and promote pulmonary arterial hypertension.Genes & genomics · 2026Article
- SIRT6 alleviates ischemic injury via orchestrating the RREB1/Snail and STC1/Smad7 signaling pathways to regulate endothelial-mesenchymal transition.Science China. Life sciences · 2026Article
- Endothelial-to-mesenchymal transition in atherosclerosis: mechanisms, therapeutic targets, and future perspectives.Frontiers in cell and developmental biology · 2026Review
- Reconceptualizing Endothelial-to-mesenchymal transition in atherosclerosis: Signaling pathways and prospective targeting strategies.Journal of advanced research · 2025Review
- Role of COUP‑TFII in cardiovascular diseases and colorectal cancer: Insights into the molecular mechanisms and clinical relevance (Review).Molecular medicine reports · 2025Review
- Engineered microtissues to model the effects of dynamic heterotypic cell signaling on iPSC-derived human hepatocyte maturation.Acta biomaterialia · 2025Article
- Inhibition of Sodium/Hydrogen Exchanger-1 in the Right Ventricle and Lung Dysfunction Induced by Experimental Pulmonary Arterial Hypertension in Rats.Journal of the American Heart Association · 2025Article
- BMPR2 Loss Activates AKT by Disrupting DLL4/NOTCH1 and PPARγ Signaling in Pulmonary Arterial Hypertension.International journal of molecular sciences · 2024Article
- N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension.Cellular & molecular biology letters · 2024Article
- NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence.Respiratory research · 2024Article
- Identification of Shared Signature Genes and Immune Microenvironment Subtypes for Heart Failure and Chronic Kidney Disease Based on Machine Learning.Journal of inflammation research · 2024Article
- Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling.Drug design, development and therapy · 2024Article
- Review
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Edward J DoughertyClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-7664-9779
Li-Yuan ChenClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0002-3596-4577
Keytam S AwadClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Gabriela A FerreyraClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Cumhur Y DemirkaleClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Ali KeshavarzClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Salina GairheClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Kathryn A JohnstonClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Madelyn E HicksClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Alexis B SandlerClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Colleen S CurranClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Janell M KrackClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.
Yi DingClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0002-6201-0509
Anthony F SuffrediniClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0003-4179-0902
Michael A SolomonClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-7400-6614
Jason M ElinoffClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0002-2376-6370
Robert L DannerClinical Center/Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-5715-3823
National Institutes of Health Clinical Center · US
Funding
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1MCellular Models of PAH-Associated Molecular Defects as a Tool for Identifying New Therapeutic TargetsZIAHL006288 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ELINOFF, JASON · 2023 to 2025
$4.1MVascular Dysfunction and InflammationZIACL000188 · CLC · CLINICAL CENTER · PI DANNER, ROBERT L · 2009 to 2025
$0kNHLBI NIH HHS R24 HL123767
Abstract
NR2F2 is expressed in endothelial cells (ECs) and
Indexed as
Pulmonary Arterial HypertensionVascular DiseasesCOUP Transcription Factor IIEndothelial CellsFamilial Primary Pulmonary HypertensionHumansInflammationIntercellular Signaling Peptides and ProteinsProto-Oncogene Proteins c-aktCOUP Transcription Factor IIDKK1 protein, humanIntercellular Signaling Peptides and ProteinsNR2F2 protein, humanProto-Oncogene Proteins c-aktcongenital heart diseaseCOUP-TF2endothelial dysfunctionNR2F2pulmonary arterial hypertension
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.