Evidence map›Paper›PMID 37039252›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2023

Pharmacoepidemiology and costs of medications dispensed during pregnancy: A retrospective population-based study.

Hannah Jackson, Luke E Grzeskowiak, Joanne Enticott, Emily Callander

Abstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hannah JacksonMonash Centre for Health Research and Implementation (MCHRI), School of Public health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-9788-8821
Luke E GrzeskowiakCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0001-8554-4696
Joanne EnticottMonash Centre for Health Research and Implementation (MCHRI), School of Public health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-4480-5690
Emily CallanderMonash Centre for Health Research and Implementation (MCHRI), School of Public health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-7233-6804

Funding

Channel 7 Children's Research FoundationMonash UniversityNational Health and Medical Research Council
6 · The paper itself

Abstract

objectiveTo describe the pharmacoepidemiology and costs associated with medications dispensed during pregnancy.

designPharmacoepidemiological study and cost analysis.

settingQueensland, Australia. POPULATION: All women who gave birth in Queensland between January 2013 and June 2018.

methodsWe used a whole-of-population linked administrative dataset, Maternity1000, to describe medications approved for public subsidy that were dispensed to 255 408 pregnant women. We describe the volume of medications dispensed and their associated costs from a Government and patient perspective.

main outcome measuresPrevalence of medication use; proportion of total dispensings; total medication costs in AUD 2020/21 ($1AUD = $0.67USD/£0.55GBP in December 2022).

resultsDuring pregnancy, 61% (95% CI 60.96-61.29%) of women were dispensed at least one medication approved for public subsidy. The mean number of items dispensed per pregnancy increased from 2.14 (95% CI 2.11-2.17) in 2013 to 2.47 (95% CI 2.44-2.51) in 2017; an increase of 15%. Furthermore, mean Government cost per dispensing increased by 41% from $21.60 (95% CI $20.99-$22.20) in 2013 to $30.44 (95% CI $29.38-$31.49) in 2017. These factors influenced the 53% increase in total Government expenditure observed for medication use during pregnancy between 2013 and 2017 ($2,834,227 versus $4,324,377); a disproportionate rise compared with the 17% rise in women's total out-of-pocket expenses observed over the same timeframe ($1,880,961 versus $2,204,415).

conclusionsPrevalence of medication use in pregnancy is rising and is associated with disproportionate and rapidly escalating cost implications for the Government.

Indexed as

ParturitionPharmacoepidemiologyAustraliaCosts and Cost AnalysisFemaleHumansPregnancyRetrospective Studiescosts and cost analysisdatasetdemographydrugsfetalmedicationobstetricpharmaceutical preparationssurveillance

Identifiers

PMID37039252
PMCPMC10952169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.