Evidence map›Paper›PMID 37038914›Full record

ArticleThe Journal of international medical research2023

Floating poly(lactic-co-glycolic acid)-based controlled-release drug delivery system for intravesical instillation.

Kai Fu, Yifei Zhou, Jia Hou, Tao Shi, Jie Ni, Xue Li, Hong Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kai FuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0001-6629-3123
Yifei ZhouDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jia HouCenter of Stomatology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Tao ShiDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jie NiDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xue LiDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Hong ZhangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the floating, structural, and controlled-release characteristics of a floating poly(lactic-co-glycolic acid) (PLGA)-based controlled-release drug delivery system, and determine the feasibility of this drug delivery system for intravesical instillation.

methodsPLGA was dissolved in dimethylacetamide, then mixed with IR780 and doxorubicin (DOX) to prepare a drug delivery system capable of solidification and flotation on water at room temperature. Preparations of PLGA, PLGA+IR780, PLGA+DOX, and PLGA+IR780+DOX were formulated. Their floating characteristics in vivo and in vitro were investigated, along with their structural and controlled-release characteristics. Preparations of saline, DOX, and PLGA+IR780+DOX were also formulated; the content of DOX in bladder tissue delivered by each preparation was determined by fluorescence microscopy.

resultsPLGA exhibited stable flotation in vivo and in vitro. A honeycomb structure was observed by scanning electron microscopy. When irradiated with a near-infrared laser, IR780 generated heat that vitrified PLGA, allowing controlled release of DOX from the drug delivery system. The PLGA+IR780+DOX preparation achieved the highest content of DOX in bladder tissue.

conclusionsOur floating PLGA-based controlled-release drug delivery system exhibited a honeycomb stabilized structure and achieved controlled release when irradiated by a near-infrared laser, making it an ideal drug delivery system for intravesical instillation.

Indexed as

Drug Delivery SystemsGlycolsAdministration, IntravesicalDelayed-Action PreparationsDoxorubicinHumansPolylactic Acid-Polyglycolic Acid CopolymerDelayed-Action PreparationsDoxorubicinGlycolsPolylactic Acid-Polyglycolic Acid Copolymerbladder cancercontrolled releasedoxorubicindrug delivery systemfeasibility studyintravesical instillationPoly(lactic-co-glycolic acid)

Identifiers

PMID37038914
PMCPMC10107978
OpenAlexW4364352282

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.