Evidence map›Paper›PMID 37038789›Full record

ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2023

Variations in protein expression associated with oral cancer.

Wei Jiang, Zhiyan He, Youmeng Zhang, Shujun Ran, Zhe Sun, Weixu Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wei JiangDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Zhiyan HeDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Youmeng ZhangDepartment of Stomatology, Eye & Ent Hospital of Fudan University, Shanghai, China.
Shujun RanDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Zhe SunDepartment of Endodontics and Operative Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Weixu ChenDepartment of Stomatology, Eye & Ent Hospital of Fudan University, Shanghai, China.
Shanghai Ninth People's Hospital · CNEye & ENT Hospital of Fudan University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDifferential protein expression of the oral microbiome is related to human diseases, including cancer.

objectiveIn order to reveal the potential relationship between oral bacterial protein expression in oral squamous cell carcinoma (OSCC), we designed this study.

methodsWe obtained samples of the same patient from cancer lesion and anatomically matched normal site. Then, we used the label free quantitative technique based on liquid chromatography tandem mass spectrometry (LC-MS/MS) to analyze the bacteria in the samples of oral squamous cell carcinoma at the protein level, so as to detect the functional proteins.

resultsProtein diversity in the cancer samples was significantly greater than in the normal samples. We identified a substantially higher number of the taxa than those detected in previous studies, demonstrating the presence of a remarkable number of proteins in the groups. In particular, proteins involved in energy production and conversion, proton transport, hydrogen transport and hydrogen ion transmembrane transport, ATP-binding cassette (ABC) transporter, PTS system, and L-serine dehydratase were enriched significantly in the experimental group. Moreover, some proteins associated with Actinomyces and Fusobacterium were highly associated with OSCC and provided a good diagnostic outcome.

conclusionThe present study revealed considerable changes in the expression of bacterial proteins in OSCC and enrich our understanding in this point.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsBacteriaChromatography, LiquidHumansSquamous Cell Carcinoma of Head and NeckTandem Mass Spectrometryenergy productionLC-MS/MSOSCCprotein expressionproton transport

Identifiers

PMID37038789
PMCPMC10200200
OpenAlexW4362696781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.