Evidence map›Paper›PMID 37038787›Full record

ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2023

Effects of Prunus Tomentosa Thumb Total Flavones on adjuvant arthritis in rats and regulation of autophagy.

Xi Chen, Lijuan Sun, Shuang Wang, Yilin Wang, Yue Zhou, Yan Li, Zihao Cheng, Yingying Wang, Yanan Jiang, Zihan Zhao and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Xi ChenCollege of Basic Medicine, Beihua University, Jilin, China.
Lijuan SunCollege of Basic Medicine, Beihua University, Jilin, China.
Shuang WangCollege of Basic Medicine, Beihua University, Jilin, China.
Yilin WangState Key Laboratory of Quality Research in Chinese Medicine, Macao University of Science and Technology, Macao, China.
Yue ZhouMingzheng Forensic Identification Centre of Jilin, Jilin, China.
Yan LiFood and Drug Inspection Institute of Jilin City, Jilin, China.
Zihao ChengCollege of Pharmacy, Beihua University, Jilin, China.
Yingying WangCollege of Basic Medicine, Beihua University, Jilin, China.
Yanan JiangCollege of Basic Medicine, Beihua University, Jilin, China.
Zihan ZhaoCollege of Pharmacy, Beihua University, Jilin, China.
Yawei XvCollege of Pharmacy, Beihua University, Jilin, China.
Chengyi ZhangCollege of Pharmacy, Beihua University, Jilin, China.
Beihua University · CNShandong Institute of Food and Drug Inspection · CNZhuhai Hospital of Integrated Traditional Chinese and Western Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a slow in taking effect systemic autoimmune disease. Prunus Tomentosa Thumb Total Flavones (PTTTF) has anti-inflammatory and antioxidant properties.

objectiveThe purpose of this study is to the PTTTF on adjuvant arthritis (AA) in rats and to explore the mechanism of autophagy.

methodsAdjuvant arthritis model was established in rats. The cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-17 (IL-17), tumor necrosis factor (TNF-α) of rat synovial tissue were determined by RT-PCR. The histopathological varieties of knee joints in AA rats were observed by HE staining. The expressions of autophagy-related proteins ATG5, ATG7, ATG12, Beclin1, Lc3II and Bcl-2 in rat synovial tissue were determined by Western Blotting.

resultsPTTTF (50, 100, 200 mg/kg) significantly inhibited inflammation in rats (P< 0.01). PTTTF significantly inhibited inflammatory factor COX in rat synovial tissue. COX-2, IL-1β, IL-6, IL-17, TNF-α expression (P< 0.05); PTTTF can significantly improve the pathological damage of rat knee joint PTTTF and can significantly inhibited the expression of autophagy-related proteins in rat synovium (P< 0.05 ).

conclusionPTTTF can inhibit adjuvant arthritis in rats and can inhibit the expression of autophagy-related proteins ATG5, ATG7, ATG12, Beclin1, Lc3II and Bcl-2.

Indexed as

Arthritis, ExperimentalAnimalsAutophagyAutophagy-Related ProteinsBeclin-1Cyclooxygenase 2Interleukin-17Interleukin-6Proto-Oncogene Proteins c-bcl-2RatsThumbTumor Necrosis Factor-alphaAutophagy-Related ProteinsBeclin-1Cyclooxygenase 2Interleukin-17Interleukin-6Proto-Oncogene Proteins c-bcl-2Tumor Necrosis Factor-alphaautophagyinflammatory factorsPrunus Tomentosa Thumb Total Flavones

Identifiers

PMID37038787
PMCPMC10200214
OpenAlexW4362696354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.