ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2023
Comparison of cell subsets in chronic obstructive pulmonary disease and controls based on single-cell transcriptome sequencing.
Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression.Frontiers in medicine · 2025Review
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, chronic obstructive pulmonary disease (COPD) significantly impacts patients' quality of life and survival as it has a high morbidity and mortality rate. COPD progression is associated with infiltration of adaptive inflammatory immune cells that form lymphatic follicles into the lung.
objectiveThe rapid development of single-cell RNA sequencing technology (scRNA-seq) provided us with powerful tools for studying the classification of cell subtypes. Additionally, it is known that COPD is closely related to the abnormal function of long-chain non-coding RNAs (lncRNAs), and scRNA-seq can help to study the expression of lncRNA from a single cell level.
methodsWe reanalyzed the scRNA-seq data of peripheral blood mononuclear cells of COPD patients downloaded from Gene Expression Omnibus (GEO) database, and performed the mRNA-based and lncRNA-based single cell clustering to compare the cell subsets in COPD and controls without COPD. Furthermore, we performed Gene Ontology (GO) enrichment analysis for the top ranked differentially expressed genes and target genes of differentially expressed lncRNAs in different cell subtypes for COPD and controls respectively.
resultsDifferences in cell subtypes were found between COPD and controls.
conclusionThis study may help us to further understand the mechanism of the human adaptive immune cell response of COPD.
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