Evidence map›Paper›PMID 37038760›Full record

ArticleBJPsych open2023

The relationship between blood-brain barrier dysfunction and neurocognitive impairments in first-episode psychosis: findings from a retrospective chart analysis.

Isabel Maurus, Sarah Wagner, Mattia Campana, Lukas Roell, Johanna Strauss, Piyumi Fernando, Susanne Muenz, Peter Eichhorn, Andrea Schmitt, Susanne Karch and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. The common misconception of blood-brain barrier terminology in psychiatry and neurology.European archives of psychiatry and clinical neuroscience · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Isabel MaurusDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.ORCID https://orcid.org/0000-0002-6208-5180
Sarah WagnerDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.
Mattia CampanaDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.ORCID https://orcid.org/0000-0003-4596-4287
Lukas RoellDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.
Johanna StraussDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.
Piyumi FernandoDepartment of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Germany.
Susanne MuenzDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.
Peter EichhornInstitute of Laboratory Medicine, University Hospital, Ludwig Maximilian University of Munich, Germany.
Andrea SchmittDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany; and Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of São Paulo, Brazil.
Susanne KarchDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.
Oliver PogarellDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.
Rolf R EngelDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany; and Max Planck Institute of Psychiatry, Germany.
Alkomiet HasanDepartment of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Germany.
Elias WagnerDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Germany.

Funding

Studienstiftung des Deutschen Volkes N/A
6 · The paper itself

Abstract

backgroundEven before the onset of psychotic symptoms, individuals with schizophrenia display cognitive impairments. Simultaneously, increasing amounts of individuals exhibit dysfunction of the blood-brain barrier (BBB). However, the impact of BBB dysfunction on neurocognitive impairment in people with first-episode psychosis has not yet been investigated.

aimsTo advance understanding of said relationship, we considered one of the largest first-episode psychosis cohorts with cerebrospinal fluid parameters available, and investigated whether BBB dysfunction is related to working memory, working speed and attention.

methodWe conducted a retrospective chart review of 121 in-patients diagnosed with a first episode of a schizophrenia spectrum disorder. Patients underwent neurocognitive testing and a lumbar puncture within routine clinical care. To define BBB dysfunction, albumin cerebrospinal fluid/serum quotients, immunoglobulin G ratios and oligoclonal band types were evaluated, and gender-specific differences investigated. Neurocognitive functioning was assessed by the Wechsler Adult Intelligence Scale, Test of Attentional Performance and Repeatable Battery for the Assessment of Neuropsychological Status. We performed simple and multiple linear regression analyses to interpret associations of interest.

resultsOf those tested, 16% showed an alteration in albumin quotients and 12% had an oligoclonal band type indicating BBB dysfunction. Notably, male patients were more likely to have an increased albumin quotient and a higher immunoglobulin G ratio than female patients. We found no significant association between BBB dysfunction and neurocognitive assessments.

conclusionsThe hypothesised relationship between BBB and neurocognitive impairments was not detectable in our retrospective cohort. Further cerebrospinal fluid-based studies with a longitudinal assessment of cognitive functioning and disease trajectory are urgently needed.

Indexed as

cerebrospinal fluidcognitionSchizophreniaworking memoryworking speed

Identifiers

PMID37038760
PMCPMC10134348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.