Evidence map›Paper›PMID 37038643›Full record

ArticleJournal of Korean medical science2023

COVID-19 Vaccine-Associated Pneumonitis in the Republic of Korea: A Nationwide Multicenter Survey.

Hongseok Yoo, Song Yee Kim, Moo Suk Park, Sung Hwan Jeong, Sung-Woo Park, Hong Lyeol Lee, Hyun-Kyung Lee, Sei-Hoon Yang, Yangjin Jegal, Jung-Wan Yoo and 12 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. mRNA: Vaccine or Gene Therapy? The Safety Regulatory Issues.International journal of molecular sciences · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 2 countries.

Hongseok Yoo *Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2227-6441
Song Yee Kim *Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8627-486X
Moo Suk Park *Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-0820-7615
Sung Hwan Jeong *Division of Allergy, Pulmonary and Critical Care Medicine, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.ORCID https://orcid.org/0000-0001-5031-1251
Sung-Woo ParkDivision of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.ORCID https://orcid.org/0000-0002-1936-0087
Hong Lyeol LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Inha University, Incheon, Korea.ORCID https://orcid.org/0000-0002-4721-567X
Hyun-Kyung LeeDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University, Busan, Korea.ORCID https://orcid.org/0000-0003-1032-0190
Sei-Hoon YangDivision of Pulmonary, Department of Internal Medicine, College of Medicine, Wonkwang University, Iksan, Korea.ORCID https://orcid.org/0000-0002-2187-5581
Yangjin JegalDivision of Pulmonary and Critical Medicine, Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.ORCID https://orcid.org/0000-0002-1935-7240
Jung-Wan YooDepartment of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.ORCID https://orcid.org/0000-0002-2137-3848
Jongmin LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-0165-5856
Hyung Koo KangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.ORCID https://orcid.org/0000-0001-9671-0944
Sun Mi ChoiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0002-0742-6085
Jimyung ParkDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0003-2655-5517
Young Whan KimDivision of Respiratory-Allergy and Clinical Immunology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-2768-2422
Jin Woo SongDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5121-3522
Joo Hun ParkDepartment of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0001-9971-7025
Won-Il ChoiDepartment of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.ORCID https://orcid.org/0000-0001-7705-0098
Hye Sook ChoiDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kyunghee University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-8387-4907
Chul ParkDivision of Pulmonary, Department of Internal Medicine, College of Medicine, Wonkwang University, Iksan, Korea.ORCID https://orcid.org/0000-0002-6031-009X
Jeong-Woong ParkDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.ORCID https://orcid.org/0000-0001-5137-3374
Man Pyo ChungDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. mpchung@skku.edu.ORCID https://orcid.org/0000-0002-5548-0764
New Generation University College · ETInha University · KRSamsung Medical Center · KRWonkwang University · KRYonsei University · KRGachon University Gil Medical Center · KRGyeongsang National University Hospital · KRInje University Ilsan Paik Hospital · KRKonkuk University Medical Center · KRKyung Hee University Dental Hospital · KRMyongji Hospital · KRSoonchunhyang University · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KRUlsan College · KRUlsan University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent reports have suggested that pneumonitis is a rare complication following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, its clinical features and outcomes are not well known. The aim of this study was to identify the clinical characteristics and outcomes of patients with vaccine-associated pneumonitis following vaccination against SARS-CoV-2.

methodsIn this nationwide multicenter survey study, questionnaires were distributed to pulmonary physicians in referral hospitals. They were asked to report cases of development or exacerbation of interstitial lung disease (ILD) associated with the coronavirus disease 2019 vaccine. Vaccine-associated pneumonitis was defined as new pulmonary infiltrates documented on chest computed tomography within 4 weeks of vaccination and exclusion of other possible etiologies.

resultsFrom the survey, 49 cases of vaccine-associated pneumonitis were identified between February 27 and October 30, 2021. After multidisciplinary discussion, 46 cases were analyzed. The median age was 66 years and 28 (61%) were male. The median interval between vaccination and respiratory symptoms was 5 days. There were 20 (43%), 17 (37%), and nine (19%) patients with newly identified pneumonitis, exacerbation of pre-diagnosed ILD, and undetermined pre-existing ILD, respectively. The administered vaccines were BNT162b2 and ChAdOx1 nCov-19/AZD1222 each in 21 patients followed by mRNA-1273 in three, and Ad26.COV2.S in one patient. Except for five patients with mild disease, 41 (89%) patients were treated with corticosteroid. Significant improvement was observed in 26 (57%) patients including four patients who did not receive treatment. However, ILD aggravated in 9 (20%) patients despite treatment. Mortality was observed in eight (17%) patients.

conclusionThese results suggest pneumonitis as a potentially significant safety concern for vaccines against SARS-CoV-2. Clinical awareness and patient education are necessary for early recognition and prompt management. Additional research is warranted to identify the epidemiology and characterize the pathophysiology of vaccine-associated pneumonitis.

Indexed as

COVID-19COVID-19 VaccinesPneumoniaAd26COVS1AgedBNT162 VaccineChAdOx1 nCoV-19FemaleHumansMaleRepublic of KoreaSARS-CoV-2VaccinationAd26COVS1BNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesCOVID-19Interstitial Lung DiseasePneumonitisSARS-CoV-2Vaccine

Identifiers

PMID37038643
PMCPMC10086377
OpenAlexW4361804248

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.