Evidence map›Paper›PMID 37038176›Full record

Trial reportBMC pregnancy and childbirth2023

Autonomic function and inflammation in pregnant women participating in a randomized controlled study of Mindfulness Based Childbirth and Parenting.

Lina Rådmark, Walter Osika, Martin Benka Wallén, Eva Nissen, Gunilla Lönnberg, Richard Bränström, Eva Henje, Renee Gardner, Emma Fransson, Håkan Karlsson and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02441595 (Mindfulness Based Childbirth and Parenting Education - RCT of Effects on Parent and Child Health), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02441595 nacompletednot on this map

Mindfulness Based Childbirth and Parenting Education - RCT of Effects on Parent and Child Health

TypeinterventionalSponsorKarolinska InstitutetRan2015 to 2018Enrolled193ConditionsParent-Child Relations, Depression, Postpartum, Stress, Physiological, Stress, PsychologicalArmsMBCP, Psychoprophylaxis
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Lina RådmarkDepartment of Clinical Neuroscience, Karolinska Institutet, Tomtebodavägen 18A, 171 77, Stockholm, Sweden.
Walter OsikaDepartment of Clinical Neuroscience, Karolinska Institutet, Tomtebodavägen 18A, 171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1583-7319
Martin Benka WallénStockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-9735-3114
Eva NissenKarolinska Institutet, Department Women's and Children's Health, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0092-0822
Gunilla LönnbergKarolinska Institutet, Department Women's and Children's Health, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4835-9325
Richard BränströmDepartment of Clinical Neuroscience, Karolinska Institutet, Tomtebodavägen 18A, 171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5889-2481
Eva HenjeDepartment of Clinical Science, Child and Adolescent Psychiatry, Umeå University, 901 85, Umeå, Sweden.ORCID http://orcid.org/0000-0001-5790-0518
Renee GardnerDepartment of Global Public Health, Karolinska Institutet, Solnavägen 1 E, 10431, Stockholm, Sweden.
Emma FranssonDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, 171 65, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9010-8522
Håkan KarlssonDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-5985-7330
Maria NiemiCenter for Social Sustainability, Department of Neurobiology, Care Sciences and Society, CSS, Center for Social Sustainability, Karolinska Institutet, Alfred Nobels allé 23, 141 83, Huddinge, Sweden. maria.niemi@ki.se.ORCID http://orcid.org/0000-0001-5407-6981
Karolinska Institutet · SEStockholm County Council · SEUmeå University · SEUppsala University · SEUppsala University Hospital · SE

Funding

Ekhagastiftelsen 2013-32Vetenskapsrådet 2014-10167
6 · The paper itself

Abstract

backgroundPregnancy and childbirth are significant events in many women's lives, and the prevalence of depressive symptoms increases during this vulnerable period. Apart from well documented cognitive, affective, and somatic symptoms, stress and depression are associated with physiological changes, such as reduced heart-rate variability (HRV) and activation of the inflammatory response system. Mindfulness Based Interventions may potentially have an effect on both HRV, inflammatory biomarkers, and self-assessed mental health. Therefore, the aim of this study was to assess the effects of a Mindfulness Childbirth and Parenting (MBCP) intervention on HRV, serum inflammatory marker levels, through an RCT study design with an active control group.

methodsThis study is a sub-study of a larger RCT, where significant intervention effects were found on perinatal depression (PND) and perceived stress. Participants were recruited through eight maternity health clinics in Stockholm, Sweden. In this sub-study, we included altogether 80 women with increased risk for PND, and blood samples and HRV measures were available from 60 of the participants (26 in the intervention and 34 in the control group).

resultsParticipants who received MBCP reported a significantly larger reduction in perceived stress and a significantly larger increase in mindfulness, compared to participants who received the active control treatment. However, in this sub-study, the intervention had no significant effect on PND, inflammatory serum markers or measures of HRV.

conclusionsNo significant differences were found regarding changes in HRV measures and biomarkers of inflammation, larger studies may be needed in the future.

trial registrationClinicalTrials.gov ID:  NCT02441595 . Registered 12 May 2015 - Retrospectively registered.

Indexed as

InflammationMindfulnessParentingParturitionPregnant PeopleStress, PsychologicalBiomarkersDepressionFemaleHumansPregnancyBiomarkersDepressionHeart rate variabilityInflammationMindfulnessPregnancy

Identifiers

PMID37038176
PMCPMC10084615
OpenAlexW4363674934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.