Evidence map›Paper›PMID 37038165›Full record

ArticleJournal of nanobiotechnology2023

Biomimetic liposomal nanozymes improve breast cancer chemotherapy with enhanced penetration and alleviated hypoxia.

Juanjuan Li, Chunai Gong, Xinlu Chen, Huanhuan Guo, Zongguang Tai, Nan Ding, Shen Gao, Yuan Gao

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Juanjuan Li *School of Pharmacy & Zhong Shan Hospital, Fudan University, Shanghai, 201206, China.
Chunai Gong *Department of Pharmacy, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200011, P. R. China.
Xinlu ChenDepartment of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Huanhuan GuoDepartment of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Zongguang TaiShanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China.
Nan DingDepartment of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Shen GaoDepartment of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. liullk@126.com.
Yuan GaoSchool of Pharmacy & Zhong Shan Hospital, Fudan University, Shanghai, 201206, China. yuan_gao@fudan.edu.cn.
Second Military Medical University · CNChanghai Hospital · CNShanghai Jiao Tong University · CNShanghai Skin Disease Hospital · CN

Funding

National Natural Science Foundation of China 81972392National Natural Science Foundation of China 81972891Science and Technology Commission of Shanghai Municipality 18JC1414200
6 · The paper itself

Abstract

backgroundDoxorubicin (Dox) has been recommended in clinical guidelines for the standard-of-care treatment of breast cancer. However, Dox therapy faces challenges such as hypoxia, acidosis, H

methodsWe developed a nanosystem H-MnO

resultsOur results shows that MP@H-MnO

conclusionsThis multifunctional biomimetic nanodelivery system exhibited antitumor efficacy in vivo and in vitro, thus having potential for the treatment of breast cancer.

Indexed as

Breast NeoplasmsNanoparticlesBiomimeticsCell Line, TumorDoxorubicinFemaleHumansHydrogen PeroxideHypoxiaLiposomesManganese CompoundsOxidesDoxorubicinHydrogen PeroxideLiposomesManganese CompoundsOxidesBiomimetic nanoparticlesBreast cancerChemotherapyHypoxiaPenetration

Identifiers

PMID37038165
PMCPMC10084658
OpenAlexW4362735535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.