Trial reportScientific reports2023
Early versus late reversal of diverting loop ileostomy in rectal cancer surgery: a multicentre randomized controlled trial.
Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01865071 (Early Closure of Temporary Loop Ileostomy After Rectal Resection for Cancer), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Closure of Temporary Loop Ileostomy After Rectal Resection for Cancer
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early versus late closure of protective ileostomy after rectal cancer surgery.International journal of colorectal disease · 2026Pooled it
- Efferent limb stimulation prior to loop ileostomy closure: a systematic review and meta-analysis.Techniques in coloproctology · 2023Pooled it
- Quality of life following ileostomy takedown: single-centre, retrospective clinical trial-does closure time matter?Techniques in coloproctology · 2025Trial
- Optimal timing of ileostomy closure after rectal surgery: A Bayesian network meta-analysis of randomized controlled trials.Langenbeck's archives of surgery · 2026Review
- Comparison of short-term outcomes among hand-sewn, stapled, and two-stage Turnbull-Cutait pull-through anastomoses in TaTME for low rectal cancer.Techniques in coloproctology · 2026Article
- Low anterior resection syndrome after sphincter-preserving surgery for rectal cancer: predictive factors and impact on perceived functional satisfaction.Discover oncology · 2026Article
- Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.Surgical endoscopy · 2026Article
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
- Effect and influencing factors of early ileostomy closure 2-4 weeks on patients with rectal cancer.Frontiers in oncology · 2026Article
- Quality of Life in Rectal Cancer Treatments: An Updated Systematic Review of Randomized Controlled Trials (2013-2023).Cancers · 2025Review
- Risk factors of the low anterior resection syndrome (LARS) after ileostomy reversal in rectal cancer patient.Scientific reports · 2024Article
- Comparative study of the risk prediction model of early postoperative frailty in elderly enterostomy patients based on machine learning methods.Frontiers in medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverting loop ileostomy has become routine in low anterior resection (LAR) for rectal cancer. The optimal time for stoma reversal is controversial. The aim of the present study was to compare the results after planned early (within 8-12 days) versus late (> 3 months) stoma reversal. The primary outcomes were morbidity and mortality, as measured by the Comprehensive Complication Index (CCI) within 30 days after stoma reversal, and the secondary outcomes were morbidity and mortality within 90 days after LAR. This was a multicentre trial including all patients scheduled for anterior low resection for rectal cancer with curative intent. Inclusion period was from April 2011 to December 2018. All patients were randomized 1:1 prior to surgery. Among 257 consecutive and eligible patients, a total of 214 patients were randomized: 107 patients to early stoma reversal and 107 to late reversal. A total of 68 patients were excluded for various reasons, and 146 patients completed the study, with 77 in the early reversal group and 69 in the late reversal group. The patients were asked to complete the Gastrointestinal Quality of Life Index before surgery (baseline) and at 6 and 12 months after LAR. Ostomy-related complications were evaluated by dedicated ostomy staff using the validated DET score. ClinicalTrials Identifier: NCT01865071. Fifty-three patients (69%) in the early reversal group and 60 patients (87%) in the late reversal group received the intended treatment. There were no significant differences in CCI within 90 days after index surgery with the LAR and within 30 days after stoma reversal between the two groups. There were no differences in patient-reported quality of life but significantly more stoma-related complications in the late reversal group. A total of 5 patients experienced anastomotic leakage (AL) after stoma reversal, 4 in the early reversal group and one in the late reversal group. Early and late stoma reversal showed similar outcomes in terms of overall complications and quality of life. The risk of developing anastomotic leakage after early ostomy reversal is a concern.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.