ArticleScientific reports2023
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07278206 (Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID), which is not on this map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Post-COVID-19 conditions: a systematic review on advanced magnetic resonance neuroimaging findings.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study.Neuroimage. Reports · 2026Article
- Pulmonary and cerebral damage in COVID-19 survivors: is there any association?Annals of medicine · 2026Article
- Cerebral arteriopathy and its role in persistent post-COVID headache and brain fog: a quantitative study.European archives of psychiatry and clinical neuroscience · 2026Article
- Article
- Cerebral perfusion features linking subclinical cardiac and aortic dysfunction to vascular brain injury.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Investigation of BOLD signal intensities in long COVID patients using 7T functional MRI.Brain, behavior, & immunity - health · 2026Article
- The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders.Journal of neuroinflammation · 2026Review
- Impaired brain intrinsic connectivity in long COVID during cognitive exertion revealed by independent component analysis.Scientific reports · 2026Article
- Viral infection states, immune control, and adult cognition: evidence across latency, persistence, and post-acute responses.Frontiers in immunology · 2026Review
- Reduced cortical brain perfusion following COVID-19 infection: impact of COVID-19 severity and relation to memory performance.Frontiers in human neuroscience · 2026Article
- A cognitive architecture for Long COVID: the interplay of brain fog, fatigue, attention and memory.Brain communications · 2026Article
- From HIV to SARS-CoV-2 associated neurological disorder ("HAND" to "SAND"): Viral infection as a "time-bomb" for the aging brain.Neuroscience applied · 2026Review
- Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.PloS one · 2026Article
- Latent brain-cognition dimension indicative of neuroinflammatory basis of Long COVID.Brain communications · 2026Article
- Post-Covid Alzheimer and Its Remediation via PROTACs Therapy: A Comprehensive Review.Health science reports · 2026Article
- Evidence of Impaired Neuroimmune System in Post-COVID Syndrome-A Whole Brain Magnetic Resonance Spectroscopy Study.Journal of medical virology · 2025Article
- Long COVID: lung pathophysiology and its relationship with cognitive dysfunction.Scientific reports · 2025Article
- Long COVID: Lung Pathophysiology and its Relationship with Cognitive Dysfunction.Research square · 2025Article
- Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment is one of the most prevalent symptoms of post Severe Acute Respiratory Syndrome COronaVirus 2 (SARS-CoV-2) state, which is known as Long COVID. Advanced neuroimaging techniques may contribute to a better understanding of the pathophysiological brain changes and the underlying mechanisms in post-COVID-19 subjects. We aimed at investigating regional cerebral perfusion alterations in post-COVID-19 subjects who reported a subjective cognitive impairment after a mild SARS-CoV-2 infection, using a non-invasive Arterial Spin Labeling (ASL) MRI technique and analysis. Using MRI-ASL image processing, we investigated the brain perfusion alterations in 24 patients (53.0 ± 14.5 years, 15F/9M) with persistent cognitive complaints in the post COVID-19 period. Voxelwise and region-of-interest analyses were performed to identify statistically significant differences in cerebral blood flow (CBF) maps between post-COVID-19 patients, and age and sex matched healthy controls (54.8 ± 9.1 years, 13F/9M). The results showed a significant hypoperfusion in a widespread cerebral network in the post-COVID-19 group, predominantly affecting the frontal cortex, as well as the parietal and temporal cortex, as identified by a non-parametric permutation testing (p < 0.05, FWE-corrected with TFCE). The hypoperfusion areas identified in the right hemisphere regions were more extensive. These findings support the hypothesis of a large network dysfunction in post-COVID subjects with cognitive complaints. The non-invasive nature of the ASL-MRI method may play an important role in the monitoring and prognosis of post-COVID-19 subjects.
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