ArticleNature communications2023
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Automated kinetic-scheme-free sorting of single-molecule fluorescence events using a deep learning based hidden-state method.Nature communications · 2026Article
- Factors modulating the assembly of human βNature structural & molecular biology · 2026Article
- Protein Frustration Reveals Orthosteric and Allosteric Active Sites in GPCR:G Protein Complexes.Journal of chemical information and modeling · 2026Article
- An Improved Cysteine-Based Labeling Strategy for GPCR Structural Dynamics Studies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Selective positive allosteric modulation of βNature communications · 2026Article
- Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway.Nature structural & molecular biology · 2026Article
- The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling.Journal of the American Chemical Society · 2026Article
- Extracellular nanobody screening using conformationally stable GPCR variants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transient ligand contacts of the intrinsically disordered N-terminus of neuropeptide YNature communications · 2025Article
- The role of intrinsically disordered domains in regulating G protein coupled receptor signaling.bioRxiv : the preprint server for biology · 2025Article
- Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation.Nature communications · 2025Article
- Signal termination of the chemokine receptor CCR9 is governed by an arrestin-independent phosphorylation mechanism.The Journal of biological chemistry · 2025Article
- Stress regulatory hormones and cancer: the contribution of epinephrine and cancer therapeutic value of beta blockers.Endocrine · 2025Review
- Supervised multi-frame dual-channel denoising enables long-term single-molecule FRET under extremely low photon budget.Nature communications · 2025Article
- The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors.Molecular pharmacology · 2025Article
- Thermodynamic role of receptor phosphorylation barcode in cannabinoid receptor desensitization.Biochemical and biophysical research communications · 2025Article
- Myosin VI drives arrestin-independent internalization and signaling of GPCRs.Nature communications · 2024Article
- Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.Nature structural & molecular biology · 2024Article
- Deep learning based local feature classification to automatically identify single molecule fluorescence events.Communications biology · 2024Article
- Conformational dynamics underlying atypical chemokine receptor 3 activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 5 countries.
Jie HengSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Yunfei HuBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Guillermo Pérez-HernándezCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Charitéplatz 1, 10117, Berlin, Germany.ORCID 0000-0002-9287-8704
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.ORCID 0000-0003-0805-4049
Jiawei ZhaoTsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing, 100084, China.
Xiuyan MaSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Xiaoou SunSchool of Medicine, Tsinghua University, Beijing, 100084, China.
Kouki KawakamiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.ORCID 0000-0002-2507-8619
Tatsuya IkutaGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.ORCID 0000-0002-8597-0609
Jienv DingBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Yujie YangBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Lujia ZhangSchool of Life Sciences, Tsinghua University, Beijing, 100084, China.
Sijia PengSchool of Life Sciences, Tsinghua University, Beijing, 100084, China.
Xiaogang NiuBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Hongwei LiBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Ramon Guixà-GonzálezCondensed Matter Theory Group, Paul Scherrer Institute, CH-5232, Villigen, PSI, Switzerland.ORCID 0000-0003-0397-9800
Changwen JinBeijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.ORCID 0000-0002-1352-2540
Peter W HildebrandCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Charitéplatz 1, 10117, Berlin, Germany.ORCID 0000-0003-0063-1104
Chunlai ChenBeijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, 100084, China. chunlai@mail.tsinghua.edu.cn.ORCID 0000-0002-0128-7766
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA. kobilka@stanford.edu.ORCID 0000-0001-5958-3990
Peking University · CNTsinghua University · CNTohoku University · JPCenter for Life Sciences · CNHumboldt-Universität zu Berlin · DEKing Center · USPaul Scherrer Institute · CHStanford University · US
Funding
THE MECHANISM OF BETA2 ADRENOCEPTOR ACTIVATIONR01NS028471 · NINDS · STANFORD UNIVERSITY · PI KOBILKA, BRIAN K · 1990 to 2021
$6.7MBeta2 Adrenoceptor Structure and Mechanism of ActivationR37NS028471 · NINDS · STANFORD UNIVERSITY · PI KOBILKA, BRIAN K · 2005 to 2011
$3.9MNINDS NIH HHS R01 NS028471NINDS NIH HHS R37 NS028471
Abstract
Advances in structural biology have provided important mechanistic insights into signaling by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is known about intrinsically disordered regions such as the carboxyl terminus (CT), which is highly flexible and not visible in GPCR structures. The β
Indexed as
Receptors, G-Protein-CoupledSignal Transductionbeta-ArrestinsCell LineReceptors, AdrenergicReceptors, Adrenergic, beta-2beta-ArrestinsReceptors, AdrenergicReceptors, Adrenergic, beta-2Receptors, G-Protein-Coupled
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.