Evidence map›Paper›PMID 37037592›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Social enrichment on the job: Complex work with people improves episodic memory, promotes brain reserve, and reduces the risk of dementia.

Max E Coleman, Meghan E H Roessler, Siyun Peng, Adam R Roth, Shannon L Risacher, Andrew J Saykin, Liana G Apostolova, Brea L Perry

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
  4. Social connection and cognitive health: A review of concepts, measures, and research priorities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  5. Article
  6. Article
  7. Occupational autonomy and cognitive function: the moderating role of educational attainment.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Real-world prediction of early-onset dementia by health record data: A multi-center machine learning study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Occupational position and complexity in relation to Black-White cognitive disparities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Factors associated with cognitive reserve according to education level.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Max E ColemanDepartment of Sociology, University of Utah, Salt Lake City, Utah, USA.
Meghan E H RoesslerDepartment of Sociology, Indiana University, Bloomington, Indiana, USA.
Siyun PengDepartment of Sociology, Indiana University, Bloomington, Indiana, USA.
Adam R RothDepartment of Sociology, Oklahoma State University, Stillwater, Oklahoma, USA.
Shannon L RisacherStark Neurosciences Research Institute, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Andrew J SaykinStark Neurosciences Research Institute, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Liana G ApostolovaStark Neurosciences Research Institute, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Brea L PerryDepartment of Sociology, Indiana University, Bloomington, Indiana, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ANDREW J SAYKIN · 2016 to 2026
$226.7M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO · 1991 to 2020
$37.3M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems BiologyU01AG072177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, DONG YOUNG, NHO, KWANGSIK TIMOTHY · 2021 to 2025
$11.2M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
Understanding how social connectedness protects older adults' cognitive health: the role of social cognitionR01AG070931 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KRENDL, ANNE CATHERINE, PERRY, BREA LOUISE · 2020 to 2024
$3.6M
Safety and modulation of ABCC9 pathways by nicorandil for the treatment of hippocampal sclerosis of aging (SMArT–HS)R01AG061111 · NIA · UNIVERSITY OF KENTUCKY · PI JICHA, GREGORY A, NELSON, PETER T. · 2019 to 2025
$3.6M
Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's DiseaseR01AG057739 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI APOSTOLOVA, LIANA G, PERRY, BREA LOUISE · 2018 to 2022
$3.5M
Multi-Domain Sensory Measures as Biomarkers of Alzheimer's Disease in Preclinical and Prodromal StagesR01AG061788 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI RISACHER, SHANNON L · 2019 to 2023
$3.0M
Epigenetic mechanisms underlying the direct and moderating effects of social connectedness on complex diseases in agingR01AG076032 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI Brea Louise Perry · 2022 to 2026
$2.9M
NCATS NIH HHS UL1 TR002529NIA NIH HHS K01 AG049050NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG057739NIA NIH HHS R01 AG061111NIA NIH HHS R01 AG061788NIA NIH HHS R01 AG068193NIA NIH HHS R01 AG070931NIA NIH HHS R01 AG076032NIA NIH HHS R01 AG078247NIA NIH HHS R24 AG065159NIA NIH HHS R37 AG057739NIA NIH HHS T32 AG071444NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG072177NIA NIH HHS U19 AG024904NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

Individuals with more complex jobs experience better cognitive function in old age and a lower risk of dementia, yet complexity has multiple dimensions. Drawing on the Social Networks in Alzheimer Disease study, we examine the association between occupational complexity and cognition in a sample of older adults (N = 355). A standard deviation (SD) increase in complex work with people is associated with a 9% to 12% reduction in the probability of mild cognitive impairment or dementia, a 0.14-0.19 SD increase in episodic memory, and a 0.18-0.25 SD increase in brain reserve, defined as the gap (residual) between global cognitive function and magnetic resonance imaging (MRI) indicators of brain atrophy. In contrast, complexity with data or things is rarely associated with cognitive outcomes. We discuss the clinical and methodological implications of these findings, including the need to complement data-centered activities (e.g., Sudoku puzzles) with person-centered interventions that increase social complexity.

Indexed as

Cognitive AgingCognitive ReserveDementiaMemory, EpisodicWorkloadAgedAtrophyBrainCognitive DysfunctionFemaleHumansJob SatisfactionMaleSocial FactorsSocial Interactionbrain reservecognitive agingcognitive reserveoccupational complexitysocial enrichment

Identifiers

PMID37037592
PMCPMC10272079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.