ArticleOphthalmology2023
Causes of Childhood Blindness in the United States Using the IRIS® Registry (Intelligent Research in Sight).
Article in Ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Incidence, mortality, and survival trends of retinoblastoma in children: a systematic review and meta-analysis of population-based studies.Italian journal of pediatrics · 2026Pooled it
- Artificial intelligence-based algorithms for the diagnosis of retinopathy of prematurity.The Cochrane database of systematic reviews · 2025Pooled it
- Incidence and risk factors for retinopathy of prematurity: A hospital-based study in Iran.Eye (London, England) · 2026Article
- Mouse and Rat Oxygen-Induced Retinopathy Models to Study Vascular Features Seen in Retinopathy of Prematurity.Bio-protocol · 2026Article
- Multi-site performance of the telemedicine retinopathy of prematurity severity score (tROP-SS).Acta ophthalmologica · 2026Article
- Computational Quantification of Mouse Retinal Vasculature Using ImageJ.Bio-protocol · 2026Article
- Automated Deep Learning Quantification of Avascular Area and Intravitreal Neovascularization in Retinal Flatmounts of Rodent Oxygen-Induced Retinopathy Models.Translational vision science & technology · 2026Article
- Multi-grader validation of the telemedicine retinopathy of prematurity severity score.Scientific reports · 2026Article
- Retinopathy of Prematurity (ROP): Are We There Yet?Medicina (Kaunas, Lithuania) · 2026Review
- WAVY OBLONG RETROGRADE MOVING SEGMENTS (WORMS) INTRAVENOUS FLUORESCEIN ANGIOGRAPHIC FINDING IN A NEONATE WITH RETINOPATHY OF PREMATURITY.Retinal cases & brief reports · 2026Article
- Early Nutritional Patterns and Metabolic Biomarkers Associated with ROP Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Oxygen blenders for prevention of retinopathy of prematurity are highly cost-effective in Uganda.Frontiers in medicine · 2026Article
- Association of Childhood Neighborhood Opportunity With Retinopathy of Prematurity.American journal of ophthalmology · 2025Article
- Elevated Ocular and Visual Disorder Risk in Developmental Disabilities: Insights from Cross-Sectional Study and Mendelian Randomization Analysis.Journal of autism and developmental disorders · 2025Article
- Disparities in Childhood Blindness Resulting from Retinopathy of Prematurity Using the IRIS® Registry.Ophthalmology · 2025Article
- Translating time: Challenges, progress, and future directions.Brain research bulletin · 2025Review
- Retinal blood flow association with age and weight in infants at risk for retinopathy of prematurity.Scientific reports · 2024Article
- Using Natural Language Processing to Identify Different Lens Pathology in Electronic Health Records.American journal of ophthalmology · 2024Article
- Efficacy of supplemental oxygen in reducing the need for laser or intravitreal bevacizumab in preterm infants with stage 2 retinopathy of prematurity.BMC ophthalmology · 2024Article
- Multi-registry analysis of patients with multiple sclerosis and neuromyelitis optica to improve capture of demographic data and compare visual outcomes.Multiple sclerosis and related disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo investigate causes of childhood blindness in the United States using the IRIS® Registry (Intelligent Research in Sight).
designCross-sectional study.
participantsPatients ≤ 18 years of age with visual acuity (VA) 20/200 or worse in their better-seeing eye in the IRIS Registry during 2018.
methodsCauses of blindness were classified by anatomic site and specific diagnoses.
main outcome measuresPercentages of causes of blindness.
resultsOf 81 164 children with 2018 VA data in the IRIS Registry, 961 (1.18%) had VA 20/200 or worse in their better-seeing eye. Leading causes of blindness were retinopathy of prematurity (ROP) in 301 patients (31.3%), nystagmus in 78 patients (8.1%), and cataract in 64 patients (6.7%). The retina was the leading anatomic site (47.7%) followed by optic nerve (11.6%) and lens (10.0%). A total of 52.4% of patients had treatable causes of blindness.
conclusionsThis analysis offers a unique cross-sectional view of childhood blindness in the United States using a clinical data registry. More than one-half of blind patients had a treatable cause of blindness. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.