ArticleProceedings of the National Academy of Sciences of the United States of America2023
Cellular production of a de novo membrane cytochrome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Photocatalytic Biohybrid Vesicles.Chemical reviews · 2026Review
- Article
- Polymer nanodiscs support the functional extraction of an artificial transmembrane cytochrome.Biochimica et biophysica acta. Biomembranes · 2025Article
- Computational design of de novo bioenergetic membrane proteins.Biochemical Society transactions · 2024Review
- Delineating redox cooperativity in water-soluble and membrane multiheme cytochromes through protein design.Protein science : a publication of the Protein Society · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Heme-containing integral membrane proteins are at the heart of many bioenergetic complexes and electron transport chains. The importance of these electron relay hubs across biology has inspired the design of de novo proteins that recreate their core features within robust, versatile, and tractable protein folds. To this end, we report here the computational design and in-cell production of a minimal diheme membrane cytochrome which successfully integrates into the cellular membrane of live bacteria. This synthetic construct emulates a four-helix bundle found in modern respiratory complexes but has no sequence homology to any polypeptide sequence found in nature. The two
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