Evidence map›Paper›PMID 37036962›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Derepression of Y-linked multicopy protamine-like genes interferes with sperm nuclear compaction in

Jun I Park, George W Bell, Yukiko M Yamashita

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026
    Article
  6. Rapid protamine evolution suppresses meiotic drive inbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. The Role of Z Chromosome Localization GeneInternational journal of molecular sciences · 2024
    Article
  12. New perspectives on the causes and consequences of male meiotic drive.Current opinion in genetics & development · 2023
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jun I ParkLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-6539-3074
George W BellWhitehead Institute for Biomedical Research, Cambridge, MA 02142.ORCID 0000-0001-6826-2507
Yukiko M YamashitaWhitehead Institute for Biomedical Research, Cambridge, MA 02142.ORCID 0000-0001-5541-0216
Whitehead Institute for Biomedical Research · USUniversity of Michigan · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Regulation of protamine incorporation and nuclear reorganization during Drosophila spermatogenesisF30HD105324 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARK, JUN IL · 2022 to 2023
$86k
Howard Hughes Medical InstituteNICHD NIH HHS F30 HD105324NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Across species, sperm maturation involves the dramatic reconfiguration of chromatin into highly compact nuclei that enhance hydrodynamic ability and ensure paternal genomic integrity. This process is mediated by the replacement of histones by sperm nuclear basic proteins, also referred to as protamines. In humans, a carefully balanced dosage between two known protamine genes is required for optimal fertility. However, it remains unknown how their proper balance is regulated and how defects in balance may lead to compromised fertility. Here, we show that a nucleolar protein,

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsChromatinDrosophilaHistonesHumansMaleProtaminesSemenSpermatogenesisSpermatozoaChromatinDrosophila ProteinsHistonesProtaminesDrosophilaprotaminespermatogenesis

Identifiers

PMID37036962
PMCPMC10120018
OpenAlexW4363677959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.