ArticlePLoS computational biology2023
In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression.
Article in PLoS computational biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico.PLoS computational biology · 2026Article
- Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits.iScience · 2026Article
- Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers.Aging cell · 2026Article
- From Monoamines to Systems Psychiatry: Rewiring Depression Science and Care (1960s-2025).Biomedicines · 2025Article
- Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models.iScience · 2025Article
- A comprehensive investigation of intracortical and corticothalamic models of the alpha rhythm.PLoS computational biology · 2025Article
- Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents.Biological psychiatry global open science · 2025Article
- Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity.PLoS computational biology · 2024Article
- Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Implications of Aperiodic and Periodic EEG Components in Classification of Major Depressive Disorder from Source and Electrode Perspectives.Sensors (Basel, Switzerland) · 2024Article
- Delta-Beta Coupling in Adolescents with Depression: A Preliminary Examination of Associations with Age, Symptoms, and Treatment Outcomes.Journal of psychophysiology · 2024Article
- In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression.Communications biology · 2024Article
- Immediate and long-term electrophysiological biomarkers of antidepressant-like behavioral effects after subanesthetic ketamine and medial prefrontal cortex deep brain stimulation treatment.Frontiers in neuroscience · 2024Article
- Magnetic seizure therapy and electroconvulsive therapy increase aperiodic activity.Translational psychiatry · 2023Article
- Predictive Biomarkers of Treatment Response in Major Depressive Disorder.Brain sciences · 2023Article
- Magnetic seizure therapy and electroconvulsive therapy increase aperiodic activity.medRxiv : the preprint server for health sciences · 2023Article
- Increased Aperiodic Neural Activity During Sleep in Major Depressive Disorder.Biological psychiatry global open science · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced cortical inhibition by somatostatin-expressing (SST) interneurons has been strongly associated with treatment-resistant depression. However, due to technical limitations it is impossible to establish experimentally in humans whether the effects of reduced SST interneuron inhibition on microcircuit activity have signatures detectable in clinically-relevant brain signals such as electroencephalography (EEG). To overcome these limitations, we simulated resting-state activity and EEG using detailed models of human cortical microcircuits with normal (healthy) or reduced SST interneuron inhibition (depression), and found that depression microcircuits exhibited increased theta, alpha and low beta power (4-16 Hz). The changes in depression involved a combination of an aperiodic broadband and periodic theta components. We then demonstrated the specificity of the EEG signatures of reduced SST interneuron inhibition by showing they were distinct from those corresponding to reduced parvalbumin-expressing (PV) interneuron inhibition. Our study thus links SST interneuron inhibition level to distinct features in EEG simulated from detailed human microcircuits, which can serve to better identify mechanistic subtypes of depression using EEG, and non-invasively monitor modulation of cortical inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.