SynthesisAging2023
Relationship between advanced maternal age and decline of endometrial receptivity: a systematic review and meta-analysis.
Synthesis in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Does endometrial receptivity array improve reproductive outcomes in euploid embryo transfer cycles? a systematic review.Frontiers in endocrinology · 2023Pooled it
- Dual Roles of Autophagy in Endometrial Fibrosis and Its Implications in Age-Related Reproductive Dysfunction.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Astragalus membranaceus ameliorates endometrial aging and restores receptivity by enhancing mitochondrial function in stromal and epithelial cells.Protein & cell · 2026Article
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- Recipient age and reproductive outcomes in donor oocyte cycles: exploring the potential contribution of uterine aging.Journal of assisted reproduction and genetics · 2026Article
- Assessment of fertility knowledge and attitudes towards parenthood and fertility preservation among tertiary-educated youths in Singapore.Journal of health, population, and nutrition · 2026Article
- Extracellular matrix: new insights into its role in female reproductive aging and potential therapeutic strategies.npj aging · 2026Review
- Impact of interval after fresh cycle cancellation on first frozen embryo transfer outcomes.Frontiers in endocrinology · 2026Article
- Association between ovarian sensitivity index and IVF-ET outcomes in women of advanced maternal age.Frontiers in endocrinology · 2026Article
- Development and Validation of an Interpretable Machine Learning Model for Prediction of the Need for Surgical Evacuation in Patients with Incomplete Abortion.Risk management and healthcare policy · 2026Article
- Advanced maternal age as a risk factor for endometrial receptivity in repeated implantation failure: intersectional transcriptomic analysis and gene validation.Frontiers in cell and developmental biology · 2026Article
- Age among women and men, time to pregnancy and risk of miscarriage.BMC medicine · 2025Article
- Regulatory Interplay of p53, AMPK, and mTOR in Decidualization: Implications for Reproductive Competence and Cancer Biology.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- The study on the clinical efficacy of endometrial receptivity analysis and influence factors of displaced window of implantation.Scientific reports · 2025Article
- High-Risk Outcomes in In Vitro Fertilization Pregnancies for Women of a Very Advanced Maternal Age: Insights from a Multi-Hospital Study in Greece.Journal of clinical medicine · 2025Article
- Factors influencing endometrial receptivity in women with recurrent implantation failure.BMC women's health · 2025Article
- Effects of acupuncture and moxibustion therapy on endometrial receptivity of infertile women withFrontiers in medicine · 2025Review
- The activation of cGAS-STING pathway causes abnormal uterine receptivity in aged mice.Aging cell · 2024Article
- Expression of Endometrial Receptivity Markers throughout the Menstrual Cycle in Women with and without Uterine Adenomyosis.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Female fertility decreases with age. A decline in oocyte quality plays a key role in reproductive problems in older women. Whether advanced maternal age (AMA) is associated with a decline in endometrial receptivity (ER) remains controversial. A systematic review and meta-analysis were conducted to evaluate the relationship between AMA and ER. Eighteen eligible studies were included in this meta-analysis. Of the 18 studies, 17, 8, 14, and 9 studies reported the impact of AMA on clinical pregnancy rate (CPR), implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR), respectively. The combined results showed a trend (without significance) toward lower CPR in women with AMA than in younger women. A similar trend of worse outcomes in terms of IR was observed in women with AMA. A significantly higher MR and lower LBR were observed in infertile women with AMA than in younger women. In conclusion, there was a slightly lower IR and CPR without significance; however, significantly increased MR and decreased LBR were observed in women with AMA than in younger women, indicating that AMA is related to the decline of ER. Further prospective cohort studies with a preimplantation genetic testing for aneuploidy model are needed to observe the relationship between AMA and ER and explore the possible mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.