ArticleJAMA neurology2023
Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model.
Article in JAMA neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Seizure risk prediction models after intracerebral hemorrhage: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- A bibliometric analysis of electroencephalogram research in stroke: current trends and future directions.Frontiers in neurology · 2025Pooled it
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Association Between Multiple Inflammation-Derived Indices and the Risk of Post-Stroke Epilepsy.CNS neuroscience & therapeutics · 2026Article
- Continuous Versus Short EEG After Ischemic Stroke: What cEEG Adds for Detecting Abnormalities and Predicting Post-Stroke Epilepsy.Annals of neurology · 2026Article
- From Acute Symptomatic Seizures to Post-Stroke Epilepsy: A Narrative Review of Diagnosis and Management.Journal of clinical medicine · 2026Review
- Nonlinear Association Between the C-Reactive Protein-To-Albumin Ratio and Post-Stroke Epilepsy Risk.CNS neuroscience & therapeutics · 2026Article
- Development and validation of a deep survival model to predict time to seizure from routine electroencephalography.Epilepsia · 2026Article
- Peri-Ictal MRI Abnormalities and Risk of Unprovoked Seizures After De Novo Status Epilepticus.Neurology · 2026Article
- The incidence and impact of early post-stroke seizures for successful endovascular stroke treatment: an individual patient data level analysis of trials.International journal of surgery (London, England) · 2026Article
- Post-stroke seizures: classification, risk prediction, and management.Frontiers in neurology · 2026Review
- Neurorehabilitation for cognitive and motor recovery: mechanisms, interventions, and translational advances.Frontiers in neurology · 2026Review
- Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy.Clinical neurophysiology practice · 2026Review
- Challenges in antiseizure medication discontinuation decisions: A qualitative study of clinicians who see patients with epilepsy.Clinical neurology and neurosurgery · 2026Article
- Epilepsy as a dynamic disease: Toward actionable, individualized seizure risk prediction.Epilepsia · 2025Review
- Epilepsy, seizures and hyperexcitability-a challenge in neurology.Neurological research and practice · 2025Article
- Status epilepticus of carotid web after carotid artery stenting: A case report.The Journal of international medical research · 2025Article
- The Role of Electroencephalography in Predicting Post-Stroke Seizures and an Updated Prognostic Model (SeLECT-EEG).Annals of neurology · 2025Article
- Risk of unprovoked seizures after discontinuation of antiseizure medication at discharge following acute symptomatic seizures.Epilepsia · 2025Article
- Mediterranean diet adherence and epilepsy: the mediating role of stroke based on a cross-sectional study.European journal of medical research · 2025Article
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Authors and funding
44 authors at 20 institutions in 11 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: Acute symptomatic seizures occurring within 7 days after ischemic stroke may be associated with an increased mortality and risk of epilepsy. It is unknown whether the type of acute symptomatic seizure influences this risk. Objective: To compare mortality and risk of epilepsy following different types of acute symptomatic seizures. Design, Setting, and Participants: This cohort study analyzed data acquired from 2002 to 2019 from 9 tertiary referral centers. The derivation cohort included adults from 7 cohorts and 2 case-control studies with neuroimaging-confirmed ischemic stroke and without a history of seizures. Replication in 3 separate cohorts included adults with acute symptomatic status epilepticus after neuroimaging-confirmed ischemic stroke. The final data analysis was performed in July 2022. Exposures: Type of acute symptomatic seizure. Main Outcomes and Measures: All-cause mortality and epilepsy (at least 1 unprovoked seizure presenting >7 days after stroke). Results: A total of 4552 adults were included in the derivation cohort (2547 male participants [56%]; 2005 female [44%]; median age, 73 years [IQR, 62-81]). Acute symptomatic seizures occurred in 226 individuals (5%), of whom 8 (0.2%) presented with status epilepticus. In patients with acute symptomatic status epilepticus, 10-year mortality was 79% compared with 30% in those with short acute symptomatic seizures and 11% in those without seizures. The 10-year risk of epilepsy in stroke survivors with acute symptomatic status epilepticus was 81%, compared with 40% in survivors with short acute symptomatic seizures and 13% in survivors without seizures. In a replication cohort of 39 individuals with acute symptomatic status epilepticus after ischemic stroke (24 female; median age, 78 years), the 10-year risk of mortality and epilepsy was 76% and 88%, respectively. We updated a previously described prognostic model (SeLECT 2.0) with the type of acute symptomatic seizures as a covariate. SeLECT 2.0 successfully captured cases at high risk of poststroke epilepsy. Conclusions and Relevance: In this study, individuals with stroke and acute symptomatic seizures presenting as status epilepticus had a higher mortality and risk of epilepsy compared with those with short acute symptomatic seizures or no seizures. The SeLECT 2.0 prognostic model adequately reflected the risk of epilepsy in high-risk cases and may inform decisions on the continuation of antiseizure medication treatment and the methods and frequency of follow-up.
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