Evidence map›Paper›PMID 37036622›Full record

ArticleCerebellum (London, England)2024

Correlation Between the SARA and A-T NEST Clinical Severity Scores in Adults with Ataxia-Telangiectasia.

Toby Major, May Yung Tiet, Rita Horvath, Anke E Hensiek

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Toby Major *School of Clinical Medicine, University of Cambridge, Hills Road, Cambridge, CB2 0SP, UK.
May Yung TietDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 2QQ, UK.
Rita HorvathDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 2QQ, UK.
Anke E HensiekDepartment of Neurology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK. ahensiek@nhs.net.
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GB

Funding

European Research Council 309548Medical Research Council MR/N025431/1Medical Research Council MR/N025431/1 and MR/V009346/1Medical Research Council MR/S005021/1Medical Research Council MR/V009346/1Wellcome TrustWellcome Trust 109915/Z/15/Z
6 · The paper itself

Abstract

Ataxia-Telangiectasia (A-T) is an autosomal recessive neurodegenerative disease associated with cerebellar ataxia and extrapyramidal features. A-T has a complex and diverse phenotype with varying rates of disease progression. The development of robust natural history studies and therapeutic trials relies on the accurate recording of phenotype using relevant and validated severity of illness indexes. We compared the commonly used Scale for the Assessment and Rating of Ataxia (SARA) and the disease-specific A-T Neurological Examination Scale Toolkit (A-T NEST), in our adult A-T cohort. We found a strong correlation between A-T NEST and the established SARA score, validating the use of A-T NEST and SARA in capturing the natural history of A-T patients.

Indexed as

Ataxia TelangiectasiaCerebellar AtaxiaNeurodegenerative DiseasesAdultDisease ProgressionHumansSeverity of Illness IndexAtaxia telangiectasiaCerebellar ataxiaSeverity of illness index

Identifiers

PMID37036622
PMCPMC10951025
OpenAlexW4362735264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.