ArticleEuropean radiology2023
Structural plasticity of the contralesional hippocampus and its subfields in patients with glioma.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Unveiling the whole-brain impact of diffuse midline glioma: cortical morphological remodeling and network alterations driven by H3 K27 mutation.Neuroradiology · 2026Article
- Contra-lesional hippocampus in low grade glioma patients with no hippocampal infiltration - a study of structural remodelling.Neuroradiology · 2026Article
- A phenome-wide hunt for risk factors of Alzheimer's disease: from metabolic clues to neuroimaging evidence.Journal of translational medicine · 2026Article
- The impact of glioblastoma on the contralesional hemisphere: insights from structural connectivity and cortical surface analysis.Neuroradiology · 2025Article
- Structural plasticity of the contralesional subfields of hippocampus and amygdala in patients with IDH-mutant astrocytoma and oligodendroglioma.Neuroradiology · 2025Article
- Beneficial Effects of Dendrobium officinale Extract on Insomnia Rats Induced by Strong Light and Noise via Regulating GABA and GABAChinese journal of integrative medicine · 2025Article
- Brain MRI morphometry for structural alterations in patients with glioma - A systematic review.European journal of radiology open · 2025Review
- Neuroplasticity in Diffuse Low-grade Gliomas: Backward Modelling of Brain-tumor Interactions Prior to Diagnosis is Needed to Better Predict Recovery after Treatment.Current neurology and neuroscience reports · 2025Review
- FastSurfer-LIT: Lesion inpainting tool for whole-brain MRI segmentation with tumors, cavities, and abnormalities.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cortical and subcortical structural changes in pediatric patients with infratentorial tumors.Diagnostic and interventional radiology (Ankara, Turkey) · 2024Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo characterize the structural plasticity of the contralesional hippocampus and its subfields in patients with unilateral glioma.
methods3D T1-weighted MRI images were collected from 55 patients with tumors infiltrating the left (HipL, n = 27) or right (HipR, n = 28) hippocampus, along with 30 age- and sex-matched healthy controls (HC). Gray matter volume differences of the contralesional hippocampal regions and three control regions (superior frontal gyrus, caudate nucleus, and superior occipital gyrus) were evaluated using voxel-based morphometry (VBM) analyses. Volumetric differences in the hippocampus and its subregional volume were measured using the FreeSurfer software.
resultsCompared with HC, patients with unilateral hippocampal glioma exhibited significantly larger gray matter volume in the contralesional hippocampus and parahippocampal regions (cluster = 571 voxels for HipL; cluster 1 = 538 voxels and cluster 2 = 88 voxels for HipR; family-wise error corrected p < 0.05). No significant alterations were found in control regions. Volumetric analyses showed the same trend in the contralesional hippocampal subregions for both patient groups, including the CA1 head, CA3 head, hippocampus amygdala transition area (HATA), fimbria, and the granule cell molecular layer of the dentate gyrus head (GC-ML-DG head). Notably, the differences of the contralesional HATA (HipL: η
conclusionsOur findings provide evidence for macrostructural plasticity of the contralateral hippocampus in patients with unilateral hippocampal glioma. Specifically, HATA and fimbria exhibit great potential in this process. KEY POINTS: • Glioma infiltration of the hippocampal regions induces a significant increase in gray matter volume on the contralateral side. • Specifically, the HATA and fimbria regions exhibit favorable plastic potential in the process of lesion-induced structural remolding.
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