ArticleEuropean radiology2023
Histogram analysis of quantitative parameters from synthetic MRI: correlations with prognostic factors in nasopharyngeal carcinoma.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 17 citations in OpenAlex.
- The value of time-dependent diffusion MRI in nasopharyngeal carcinoma: correlation with prognostic factors.European radiology · 2026Article
- The prognostic value of intra- and peritumoral habitat analysis in nasopharyngeal carcinoma: combining IVIM and ASL.European radiology · 2026Article
- Delta Histogram Analysis of Synthetic MRI for Evaluating Grade and Cellular Proliferation of Meningioma.Radiology. Imaging cancer · 2026Article
- Non-Gaussian diffusion MRI using CTRW and FROC models for early treatment response assessment in nasopharyngeal carcinoma.BMC medical imaging · 2026Article
- Advancing breast cancer diagnosis: a combined approach using deep learning-reconstructed diffusion-weighted imaging and Synthetic MRI.Frontiers in oncology · 2026Article
- Whole-tumor histogram analysis of synthetic MRI for the differentiation of benign and malignant soft-tissue tumors: a preliminary study.European radiology · 2025Article
- A novel synthetic MRI for discrimination of oral cavity and oropharynx malignancy.BMC medical imaging · 2025Article
- Whole-tumor histogram analysis of synthetic MRI relaxation maps for nasopharyngeal carcinoma: correlations with histopathologic components.Japanese journal of radiology · 2025Article
- Whole-tumor histogram analysis of synthetic MRI for discriminating benign from malignant sinonasal tumors: correlations with histopathologic factors.Quantitative imaging in medicine and surgery · 2025Article
- Prediction of induction chemotherapy response in locoregionally advanced nasopharyngeal carcinoma based on three pretreatment non-Gaussian diffusion MRI models.BMC medical imaging · 2025Article
- Technical aspects and clinical applications of synthetic MRI: a scoping review.Diagnosis (Berlin, Germany) · 2025Article
- Histogram analysis of continuous-time random walk and restrictive spectrum imaging for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma.Frontiers in oncology · 2025Article
- Synthetic MRI and amide proton transfer-weighted MRI for differentiating between benign and malignant sinonasal lesions.European radiology · 2024Article
- Multiparametric approach with synthetic MR imaging for diagnosing salivary gland lesions.Japanese journal of radiology · 2024Article
- Nomogram of magnetic resonance imaging (MRI) histogram analysis to predict telomerase reverse transcriptase promoter mutation status in glioblastoma.Quantitative imaging in medicine and surgery · 2024Article
- Histogram analysis of MR quantitative parameters: are they correlated with prognostic factors in prostate cancer?Abdominal radiology (New York) · 2024Article
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the correlation between histogram parameters derived from synthetic magnetic resonance imaging (SyMRI) and prognostically relevant factors in nasopharyngeal carcinoma (NPC).
methodsFifty-nine consecutive NPC patients were prospectively enrolled. Quantitative parameters (T1, T2, and proton density (PD)) were obtained by outlining the three-dimensional volume of interest (VOI) of all lesions. Then, histogram analysis of these quantitative parameters was performed and the correlations with prognostically relevant factors were assessed. By choosing appropriate cutoff, we divided the sample into two groups. Independent-samples t test/Mann-Whitney U test was used and ROC curve analysis was further processed.
resultsHistogram parameters of the T1, T2, and PD maps were positively correlated with the Ki-67 expression levels, and PD_mean was the most representative parameter (AUC: 0.861). The PD map exhibited good performance in differentiating epidermal growth factor receptor (EGFR) expression levels (AUC: 0.706~0.732) and histological type (AUC: 0.650~0.660). T2_minimum was highest correlated with Epstein-Barr virus (EBV) DNA levels (r = - 0.419), and PD_75th percentile exhibited the highest performance in distinguishing positive and negative EBV DNA groups (AUC: 0.721). T1_minimum was statistically correlated with EA-IgA expression (r = - 0.313). Additionally, several histogram parameters were negatively correlated with tumor stage (T stage: r = - 0.259 ~ - 0.301; N stage: r = - 0.348 ~ - 0.456; clinical stage: r = - 0.419).
conclusionsHistogram parameters of SyMRI could reflect tissue intrinsic characteristics and showed potential value in assessing the Ki-67 and EGFR expression levels, histological type, EBV DNA level, EA-IgA, and tumor stage. KEY POINTS: • SyMRI combined with histogram analysis may help clinicians to assess different prognostic factor statuses in nasopharyngeal carcinoma. • The PD map exhibited good discriminating performance in the Ki-67 and EGFR expression levels. • Histogram parameters of SyMRI were negatively correlated with EBV-related blood biomarkers and TNM stage.
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