Evidence map›Paper›PMID 37036113›Full record

ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2023

Support-Giving Is Associated With Lower Systemic Inflammation.

Tristen K Inagaki, Gabriella M Alvarez, Edward Orehek, Rebecca A Ferrer, Stephen B Manuck, Nicole M Abaya, Keely A Muscatell

Abstract read
In one paragraph

Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Prosocial helping behaviors attenuate accelerated cognitive decline driven by APOE ε4.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tristen K InagakiDepartment of Psychology, San Diego State University, San Diego, CA, USA.ORCID 0000-0002-8825-2637
Gabriella M AlvarezDepartment of Psychology & Neuroscience, Lineberger Comprehensive Cancer Center, Carolina Population Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Edward OrehekDepartment of Psychology, San Diego State University, San Diego, CA, USA.ORCID 0000-0003-0623-0846
Rebecca A FerrerBasic Biobehavioral and Psychological Sciences Branch, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0003-1069-9989
Stephen B ManuckDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Nicole M AbayaDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Keely A MuscatellDepartment of Psychology & Neuroscience, Lineberger Comprehensive Cancer Center, Carolina Population Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7893-5565

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
NCATS NIH HHS UL1 TR002373NCRR NIH HHS UL1 RR025011NHLBI NIH HHS P01 HL040962NIA NIH HHS P01 AG020166NIA NIH HHS U19 AG051426
6 · The paper itself

Abstract

backgroundSupport-giving has emerged as a health-relevant social behavior, such that giving more support is associated with better physical health. However, biological mechanisms by which support-giving and health are linked remain unclear. Whether support-giving uniquely relates to health relative to other psychosocial factors is also an open research question. PURPOSE: Two studies test the hypothesis that support-giving is uniquely (over-and-above other psychosocial factors) related to lower systemic inflammation, a biological correlate of health.

methodsCross-sectional associations of support-giving with markers of systemic inflammation (i.e., interleukin-6 [IL-6], C-reactive protein [CRP]) were examined in two independent samples of midlife adults (Study 1, n = 746; Study 2, n = 350).

resultsConsistent with hypotheses, giving to more social targets (to family and friends, and also volunteering for various causes), but not receiving support from similar targets, was associated with lower IL-6. In conceptual replication and extension with a different measure of support-giving, higher frequency of support-giving behavior was associated with lower IL-6, even after adjusting for social network size and individual differences in social desirability. There were no associations between support-giving and CRP in either sample.

conclusionsFuture research needs to establish causality and directly test mechanistic pathways, but together, findings reaffirm the health-relevance of support-giving behavior and shed light on a promising biological mechanism by which such effects may occur.

Indexed as

InflammationInterleukin-6AdultC-Reactive ProteinCross-Sectional StudiesHumansSocial BehaviorC-Reactive ProteinInterleukin-6AltruismInflammationProsocial behaviorSocial supportVolunteering

Identifiers

PMID37036113
PMCPMC10413322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.